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Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation.
A wide array of phenolic substances, particularly those present in edible and medicinal plants, have been reported to possess substantial anticarcinogenic and antimutagenic activities. The majority… Expand
Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals.
A wide array of dietary phytochemicals have been reported to induce the expression of enzymes involved in both cellular antioxidant defenses and elimination/inactivation of electrophilic carcinogens.… Expand
Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals.
Oxidative stress has been implicated in various pathological conditions including cancer. However, the human body has an intrinsic ability to fight against oxidative stress. A wide array of phase 2… Expand
Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances.
- Y. Surh
- Chemistry, Medicine
- Mutation research
- 16 July 1999
Recently, considerable attention has been focused on identifying naturally occurring chemopreventive substances capable of inhibiting, retarding, or reversing the multi-stage carcinogenesis. A wide… Expand
Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1.
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential component of cellular defense against a vast variety of endogenous and exogenous insults, including oxidative stress. Nrf2 acts as a… Expand
Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1.
Recently, considerable attention has been focused on identifying dietary and medicinal phytochemicals that can inhibit, retard or reverse the multi-stage carcinogenesis. Spices and herbs contain… Expand
Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells.
Resveratrol, a triphenolic stilbene present in grapes and other plants, has striking antioxidant and anti-inflammatory activities which have been considered to be responsible for the beneficial… Expand
Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress
- Y. Surh, J. Kundu, M. Li, H. Na, Young-nam Cha
- Biology, Medicine
- Archives of pharmacal research
- 29 August 2009
Nitrosative stress caused by reactive nitrogen species such as nitric oxide and peroxynitrite overproduced during inflammation leads to cell death and has been implicated in the pathogenesis of many… Expand
Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger.
- Y. Surh, K. K. Park, K. S. Chun, L. J. Lee, E. Lee, S. S. Lee
- Chemistry, Medicine
- Journal of environmental pathology, toxicology…
Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been widely used as a dietary spice, as well as in traditional oriental medicine. The rhizome of ginger contains pungent vanillyl ketones,… Expand
Expression of stress-response ATF3 is mediated by Nrf2 in astrocytes
Activating Transcription Factor 3 (ATF3), a member of the ATF/CREB family, is induced rapidly by various stresses. Its induction mechanism and role in response to changes in cellular redox status,… Expand