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Effects of iron limitation on the expression of metabolic genes in the marine cyanobacterium Trichodesmium erythraeum IMS101.
Iron deficiency in axenic cultures of Trichodesmium erythraeum IMS101 led to significant declines in both nitrogen fixation rates and photochemical energy conversion efficiency, accompanied byExpand
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Silencing of two alternative splicing-derived mRNA variants of chitin synthase 1 gene by RNAi is lethal to the oriental migratory locust, Locusta migratoria manilensis (Meyen).
Chitin synthases are crucial enzymes responsible for chitin biosynthesis in fungi, nematodes and arthropods. We characterized two alternative splicing-derived variants of chitin synthase 1 geneExpand
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A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia
One major unanswered question in neuroscience is how the brain transitions between conscious and unconscious states. General anesthetics offer a controllable means to study these transitions.Expand
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Sensitive red protein calcium indicators for imaging neural activity
Genetically encoded calcium indicators (GECIs) allow measurement of activity in large populations of neurons and in small neuronal compartments, over times of milliseconds to months. AlthoughExpand
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The Conserved Endoribonuclease YbeY Is Required for Chloroplast Ribosomal RNA Processing in Arabidopsis1
The Arabidopsis endoribonuclease YbeY is required for chloroplast rRNA processing, and its deficiency reduces chloroplast activity and normal plant growth. Maturation of chloroplast ribosomal RNAsExpand
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Genome‐wide SNP genotyping identifies the Stereocilin (STRC) gene as a major contributor to pediatric bilateral sensorineural hearing impairment
Hearing loss is the most prevalent sensory perception deficit in humans, affecting 1/500 newborns, can be syndromic or nonsyndromic and is genetically heterogeneous. Nearly 80% of inheritedExpand
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High-performance calcium sensors for imaging activity in neuronal populations and microcompartments
Calcium imaging with genetically encoded calcium indicators (GECIs) is routinely used to measure neural activity in intact nervous systems. GECIs are frequently used in one of two different modes: toExpand
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Two chitinase 5 genes from Locusta migratoria: molecular characteristics and functional differentiation.
The duplication of chitinase 5 (Cht5) into two to five different genes has been reported only in mosquito species to date. Here, we report the duplication of Cht5 genes (LmCht5-1 and LmCht5-2) in theExpand
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Identification of chemical compounds that induce HIF-1alpha activity.
  • M. Xia, R. Huang, +6 authors C. Austin
  • Biology, Medicine
  • Toxicological sciences : an official journal of…
  • 1 November 2009
Cellular metabolism depends on the availability of oxygen and the major regulator of oxygen homeostasis is hypoxia-inducible factor 1 (HIF-1), a highly conserved transcription factor that plays anExpand
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Phosphatidylinositol (4,5) Bisphosphate Controls T Cell Activation by Regulating T Cell Rigidity and Organization
Here we investigate the role of Phosphatidylinositol (4,5) bisphosphate (PIP2) in the physiological activation of primary murine T cells by antigen presenting cells (APC) by addressing two principalExpand
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