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Association between Helicobacter pylori infection and interleukin 1β polymorphism predispose to CpG island methylation in gastric cancer
Patients with H pylori infection and IL1 polymorphism, by the production of IL1β, are predisposed to gastric cancer development through the CpG island methylation pathway. Expand
Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers.
It is concluded that SP-600125 inhibits proliferation, induces apoptosis and causes cell cycle arrest in gastrointestinal cancer cells, indicating that JNK inhibitors have an anti-tumor effect and are potential therapeutic agents for cancers. Expand
Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers.
Down-regulation of XAF1 in association with hypermethylation was detected in 3 of 4 human gastric cancer cell lines and 6 of 8 colon cancer cell Lines, and of the 4 promoter fragments, F291 showed the highest promoter activity, which could be down-regulated obviously by the mutation of particular CpG sites. Expand
Oridonin derivative ameliorates experimental colitis by inhibiting activated T‐cells and translocation of nuclear factor‐kappa B
The modulatory functions of HAO472 in a mouse model of trinitrobenzene sulfonic acid (TNBS)‐induced colitis are investigated to confirm the potential therapeutic efficacy of this drug against inflammatory bowel disease. Expand
XAF1 mediates apoptosis through an extracellular signal‐regulated kinase pathway in colon cancer
The aim of the study was to investigate the correlation between the ERK1/2 signaling pathway and XAF1 in colon cancer. Expand
All-trans retinoic acid induces XAF1 expression through an interferon regulatory factor-1 element in colon cancer.
XAF1 participates in ATRA-induced growth suppression through IRF-1-mediated transcriptional regulation and is independent of the promoter methylation and the subcellular distribution of XIAP. Expand
Oridonin inhibits pancreatic cancer cell migration and epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling pathway
- Q. Liu, K. Chen, Qiao Ye, Xiaohua Jiang, Y. Sun
- Chemistry, Medicine
- Cancer Cell International
- 22 July 2016
ORI can inhibit pancreatic cancer cell SW1990 migration and EMT by down-regulating Wnt/β-catenin signal transduction in vitro and in vivo and can be potentially and effectively used in the clinical management of pancreatic cancers. Expand
Cigarette Smoking and Mortality in Patients With Pancreatic Cancer: A Systematic Review and Meta-analysis.
Cigarette smoking was associated with an increase in total mortality for patients with pancreatic cancer, and this effect of smoking is independent of alcohol use, body mass index, and history of diabetes but is modified by tumor stage and study settings. Expand
[The effects of octreotide on portal hemodynamics in patients with liver cirrhosis].
Octreotide may have potential prophylactic effect in prevention of early variceal re-bleeding in cirrhotic patients with portal hypertension. Expand
[The study of regulation of connective tissue growth factor gene promoter by transforming growth factor beta1 in pancreatic stellate cells].
- Y. Sun, Yong-ping Zhang, M. Qiao, H. Fu, Yao-zong Yuan
- Biology, Medicine
- Zhonghua yi xue za zhi
- 2 August 2004
TGF-beta(1) could enhance the activities of pCTGF-luc in PSCs by means of time and dose dependently and stimulate the expression of CTGF gene promoter at the high level in a short time. Expand