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Induction of T‐cell‐mediated skin disease specific for antigen transgenically expressed in keratinocytes
TLDR
It is concluded that the transgenic mice system provides a useful model for autoimmune skin diseases and will aid understanding of the pathomechanism of drug eruption, viral exanthema, and graft‐versus‐host disease. Expand
Induction of beta-defensin 3 in keratinocytes stimulated by bacterial lipopeptides through toll-like receptor 2.
TLDR
These studies strongly suggest that the TLR2-MyD88-dependent pathway in keratinocytes is essential for antimicrobial activity in vivo. Expand
ΔNp63 Controls a TLR3-Mediated Mechanism That Abundantly Provides Thymic Stromal Lymphopoietin in Atopic Dermatitis
TLDR
The results indicate that ΔNp63lo/- keratinocytes generate TSLP through a putative autocrine and/or paracrine pathway upon TLR3 stimulation within AD lesions, since moieties of damaged cells and pathogens stimulateTLR3. Expand
Effects of foot care intervention including nail drilling combined with topical antifungal application in diabetic patients with onychomycosis
TLDR
Foot care intervention including nail drilling combined with topical antifungal application had effects on onychomycosis and achieved cure in some patients with SWO and increased patients’ awareness of foot care, showing educational effects. Expand
Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice
TLDR
Physiologically, adipose Pten mRNA decreased with exposure to cold and increased with obesity, which were linked to the mRNA alterations of mitochondriagenesis, which suggest that altered expression of adipOSE Pten could regulate insulin sensitivity and energy expenditure. Expand
Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis
TLDR
This work has shown that Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis and its importance as an indicator of future treatment strategy is still under investigation. Expand
Induction of β-defensin 3 in keratinocytes stimulated by bacterial lipopeptides through toll-like receptor 2
TLDR
In vivo studies strongly suggest that the TLR2–MyD88-dependent pathway in keratinocytes is essential for antimicrobial activity in vivo. Expand
C‐terminal Src kinase controls development and maintenance of mouse squamous epithelia
TLDR
It is demonstrated that the Src/Csk circuit plays crucial roles in development and maintenance of epithelia by controlling cytoskeletal organization as well as phenotypic conversion linked to inflammatory events. Expand
Clinical and epidemiological analysis in 149 cases of rhododendrol‐induced leukoderma
TLDR
Investigation of patient‐specific factors that may affect the extent of depigmentation or repigmentation, as well as development of vitiligo vulgaris, suggested that severe chemical damage of melanocytes by rhododendrol leads to a higher risk of developing vitiliga vulgaris through the possible involvement of an immune reaction. Expand
Severe atopic dermatitis associated with transient hypogammaglobulinemia of infancy
49–50. 2 Verma SB, Wollina U. Acne keloidalis nuchae: another cutaneous symptom of metabolic syndrome, truncal obesity, and impending/overt diabetes mellitus? Am J Clin Dermatol 2010; 11: 433–436. 3Expand
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