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An Essential Role for PICK1 in NMDA Receptor-Dependent Bidirectional Synaptic Plasticity
PICK1 is a calcium-sensing, PDZ domain-containing protein that interacts with GluR2 and GluR3 AMPA receptor (AMPAR) subunits and regulates their trafficking. Although PICK1 has been principallyExpand
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Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating
  • Y. Shi, Y. Suh, +4 authors R. Nicoll
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 30 August 2010
Glutamate receptors of the AMPA subtype (AMPARs) mediate fast synaptic transmission in the brain. These ionotropic receptors rely on auxiliary subunits known as transmembrane AMPAR regulatoryExpand
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A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking
Regulated exocytosis is essential for many biological processes and many components of the protein trafficking machinery are ubiquitous. However, there are also exceptions, such as SNAP-25, aExpand
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Cornichon Proteins Determine the Subunit Composition of Synaptic AMPA Receptors
Cornichon-2 and cornichon-3 (CNIH-2/-3) are AMPA receptor (AMPAR) binding proteins that promote receptor trafficking and markedly slow AMPAR deactivation in heterologous cells, but their role inExpand
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Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells.
Chronic hyperglycemia is toxic to pancreatic beta-cells, impairing cellular functioning as observed in type 2 diabetes; however, the mechanism underlying beta-cell dysfunction and the resultingExpand
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Crucial roles of neuronatin in insulin secretion and high glucose-induced apoptosis in pancreatic beta-cells.
Neuronatin (Nnat) was initially identified as a selectively-expressed gene in neonatal brains, but its expression has been also identified in pancreatic beta-cells. Therefore, to investigate theExpand
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AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis.
We previously demonstrated that chronic high glucose (33.3 mM) induced beta-cell dysfunction and apoptosis through glucokinase (GCK) downregulation, but the exact mechanisms involved remain unclear.Expand
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Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs.
Human CD99 (MIC2) is a 32 kDa cell surface protein and its encoding gene is localized to the pseudoautosomal regions of both Xp and Yp chromosomes. Although sequences of several genes such as humanExpand
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Rapid divergency of rodent CD99 orthologs: implications for the evolution of the pseudoautosomal region.
The human pseudoautosomal region 1 (PAR1) is essential for the obligatory X-Y crossover in male meiosis. Despite its critical role, comparative studies of human and mouse pseudoautosomal genes haveExpand
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Ectopic expression of Neuronatin potentiates adipogenesis through enhanced phosphorylation of cAMP-response element-binding protein in 3T3-L1 cells.
  • Y. Suh, W. Kim, +6 authors M. Jung
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 18 November 2005
Neuronatin (Nnat) is selectively expressed in the neonatal brain and is involved in neuronal differentiation during brain development. However, Nnat also appears to be abundantly expressed in adiposeExpand
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