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Auxin transport inhibitors block PIN1 cycling and vesicle trafficking
TLDR
It is shown that the seemingly static localization of PIN1 results from rapid actin-dependent cycling between the plasma membrane and endosomal compartments, suggesting that PIN1 cycling is of central importance for auxin transport and that Auxin transport inhibitors affect efflux by generally interfering with membrane-trafficking processes. Expand
Vacuolar H+-ATPase Activity Is Required for Endocytic and Secretory Trafficking in Arabidopsis[W]
TLDR
The results suggest the convergence of the early endocytic and secretory trafficking pathways in the TGN, where VHA-a1 is preferentially found in the trans-Golgi network, the main sorting compartment of the secretory pathway. Expand
Plk4-induced centriole biogenesis in human cells.
TLDR
It is shown that overexpression of Polo-like kinase 4 (Plk4) in human cells induces centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole, and that centrioles elongate through insertion of alpha-/beta-tubulin underneath a CP110 cap. Expand
Clathrin-Mediated Constitutive Endocytosis of PIN Auxin Efflux Carriers in Arabidopsis
TLDR
It is demonstrated that clathrin-dependent endocytosis is operational in plants and constitutes the predominant pathway for the internalization of numerous plasma-membrane-resident proteins including PIN auxin efflux carriers. Expand
Rapid, combinatorial analysis of membrane compartments in intact plants with a multicolor marker set.
TLDR
A new vector series is designed, and a large number of stably transformed plants expressing membrane protein fusions to spectrally distinct, fluorescent tags are generated, demonstrating the power of this multicolor 'Wave' marker set for rapid, combinatorial analysis of plant cell membrane compartments, both in live-imaging and immunoelectron microscopy. Expand
Pausing of Golgi Bodies on Microtubules Regulates Secretion of Cellulose Synthase Complexes in Arabidopsis[W]
TLDR
The results indicate that cellulose synthesis is coordinated with growth status and regulated in part through CSC internalization, and find that CSC insertion in the plasma membrane is regulated by pauses of the Golgi apparatus along cortical microtubules, which support a model in which cortical micro Tubules not only guide the trajectories of CSCs in the Plasma membrane, but also regulate the insertion and internalization of C SCs. Expand
Auxin inhibits endocytosis and promotes its own efflux from cells
TLDR
The data imply a previously undescribed mode of plant hormone action: by modulating PIN protein trafficking, auxin regulates PIN abundance and activity at the cell surface, providing a mechanism for the feedback regulation of auxin transport. Expand
Cep164, a novel centriole appendage protein required for primary cilium formation
TLDR
One newly identified protein, Cep164, was indispensable for PC formation and hence characterized in detail and identified as an excellent marker for these structures. Expand
The Polo kinase Plk4 functions in centriole duplication
TLDR
It is identified that Plk4 is required — in cooperation with Cdk2, CP110 and Hs-SAS6 — for the precise reproduction of centrosomes during the cell cycle and this findings provide an attractive explanation for the crucial function of PlK4 in cell proliferation. Expand
Rootletin forms centriole-associated filaments and functions in centrosome cohesion
TLDR
The ability of rootletin to form centriole-associated fibers suggests a dynamic model for centrosome cohesion based on entangling filaments rather than continuous polymeric linkers. Expand
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