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Selenium-Based S-Adenosylmethionine Analog Reveals the Mammalian Seven-Beta-Strand Methyltransferase METTL10 to Be an EF1A1 Lysine Methyltransferase
The utility of the synthetic cofactor ProSeAM as a chemical probe for the identification of non-histone substrates of KMTs of lysine methylation is emphasized.
The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes
It is reported that METTL9 is a broad-specificity methyltransferase that mediates the formation of the majority of 1MH present in mouse and human proteomes, and the results establishMETTL9-mediated 1MH as a pervasive protein modification, thus setting the stage for further functional studies on protein histidine methylation.
Development of bis-thiourea-type organocatalyst for asymmetric Baylis–Hillman reaction
Organocatalytic asymmetric nitroaldol reaction: cooperative effects of guanidine and thiourea functional groups.
- Y. Sohtome, Nobuko Takemura, K. Takada, Rika Takagi, Toshitsugu Iguchi, K. Nagasawa
- ChemistryChemistry, an Asian journal
- 3 September 2007
On the basis of studies of structure and catalytic-activity relationships, a plausible guanidine-thiourea cooperative mechanism and a transition state of the catalytic reactions are proposed and may lead to the development of new chiral surfactants.
Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification.
Guanidine‐Thiourea Bifunctional Organocatalyst for the Asymmetric Henry (Nitroaldol) Reaction
Novel bifunctional catalysts having guanidine and thiourea functional groups were developed for the asymmetric Henry (nitroaldol) reaction and efficiently promoted the Henry reaction.
Diastereoselective and Enantioselective Henry (Nitroaldol) Reaction Utilizing a Guanidine‐Thiourea Bifunctional Organocatalyst
A highly enantio- and diastereoselective Henry reaction of various aldehydes with nitroethane was developed using the guanidine-thiourea bifunctional catalyst 1 (syn selectivity of 86:14 to 99:1 with…
Entropy-controlled catalytic asymmetric 1,4-type Friedel-Crafts reaction of phenols using conformationally flexible guanidine/bisthiourea organocatalyst.
- Y. Sohtome, B. Shin, Natsuko Horitsugi, Rika Takagi, K. Noguchi, K. Nagasawa
- ChemistryAngewandte Chemie
- 24 September 2010
The primary aim of this study was to extend the newly developed organocatalytic system to asymmetric 1,4-additions reactions of nitroolefins and uncovered a unique catalytic stereodiscrimination process controlled only by differences in the activation entropies.
Dynamic asymmetric organocatalysis: cooperative effects of weak interactions and conformational flexibility in asymmetric organocatalysts.
This review describes recent advances by our research group in the design and applications of conformationally flexible guanidine/bisthiourea organocatalysts to facilitate unique bond-forming…
Catalytic asymmetric cyclopropanation of enones with dimethyloxosulfonium methylide promoted by a La-Li3-(biphenyldiolate)3 + NaI complex.
- H. Kakei, T. Sone, Y. Sohtome, S. Matsunaga, M. Shibasaki
- ChemistryJournal of the American Chemical Society
- 11 October 2007
The present method is complementary to the previously reported catalytic enantioselective methods in terms of ylides used, and trans products were exclusively obtained in good yield and high enantiOSElectivity.