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Alpha-tomatine inactivates PI3K/Akt and ERK signaling pathways in human lung adenocarcinoma A549 cells: effect on metastasis.
TLDR
The results showed alpha-tomatine could inhibit the metastatic ability of A549 cells by reducing MMP-2, M MP-9, and u-PA activities through suppressing phosphoinositide 3-kinase/Akt (PI3K-Akt) or ERK1/2 signaling pathway and inhibition NF-kappaB or AP-1 binding activities. Expand
Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression
TLDR
It is suggested that diosgenin inhibited migration and invasion of PC-3 cells by reducing MMPs expression and inhibited ERK, JNK and PI3K/Akt signaling pathways as well as NF-κB activity. Expand
Chemoinhibitory effect of mulberry anthocyanins on melanoma metastasis involved in the Ras/PI3K pathway.
TLDR
The findings proved the inhibitory effect of MACs on the growth and metastasis of B16-F1 cells and indicated that MACs might be offered for future application as an antimetastatic agent. Expand
Alpha-mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen expression through the JNK signaling pathway.
TLDR
Results proved that alpha-mangostin might be offered further application as an antimetastatic agent in the cancer cell metastasis process through the suppression of the JNK1/2 signaling pathway and inhibition of NF-kappaB and AP-1 binding activity. Expand
α-Solanine inhibits human melanoma cell migration and invasion by reducing matrix metalloproteinase-2/9 activities.
TLDR
Results suggested that α-solanine inhibited migration and invasion of A2058 cells by reducing MMP-2/9 activities and inhibited JNK and PI3K/Akt signaling pathways as well as NF-κB activity, revealing new therapeutic potential for α-Solanine in anti-metastatic therapy. Expand
Acacetin, a flavonoid, inhibits the invasion and migration of human prostate cancer DU145 cells via inactivation of the p38 MAPK signaling pathway
TLDR
Results proved acacetin might be offered further application as an antimetastatic agent by suppressing p38 MAPK signaling pathway and inhibiting NF-κB- or AP-1-binding activity. Expand
α-Mangostin Suppresses Phorbol 12-myristate 13-acetate-Induced MMP-2/MMP-9 Expressions via αvβ3 Integrin/FAK/ERK and NF-κB Signaling Pathway in Human Lung Adenocarcinoma A549 Cells
TLDR
Results indicated α-mangostin is a novel, effect, anti-metastatic agent that functions by downregulating M MP-2 and MMP-9 gene expressions. Expand
Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis
TLDR
It is suggested that apigenin inhibits T-24 cells proliferation via blocking cell cycle progression and inducing apoptosis and a potential anticancer activity of apigenIn is discovered against T- 24 cells. Expand
Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells
TLDR
The results suggest that nobiletin can reduce invasion and migration of AGS cells, and such a characteristic may be of great value in the development of a potential cancer therapy. Expand
α-Tomatine Suppresses Invasion and Migration of Human Non-Small Cell Lung Cancer NCI-H460 Cells Through Inactivating FAK/PI3K/Akt Signaling Pathway and Reducing Binding Activity of NF-κB
TLDR
Investigation of the anti-metastatic effect of α-tomatine in NCI-H460 human non-small cell lung cancer cells showed that α- tomatine significantly suppressed the abilities of the adhesion, invasion, and migration of NCI -H460 cells under non-cytotoxic concentrations. Expand
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