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- Publications
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Isolation, characterization and acetylcholinesterase inhibitory activity of alkaloids from roots of Stemona sessilifolia.
- Dong-Hai Lai, Z. Yang, Wei-wei Xue, J. Sheng, Y. Shi, X. Yao
- Chemistry, Medicine
- Fitoterapia
- 1 September 2013
Two new alkaloids, named stenine A (1) and stenine B (2), along with the known compounds neostenine (3), stenine (4) and neotuberostemonine (5), were isolated from the roots of Stemona sessilifolia.… Expand
A Peroxidase-linked Spectrophotometric Assay for the Detection of Monoamine Oxidase Inhibitors
- Kangkang Zhi, Zhongduo Yang, J. Sheng, Zongmei Shu, Y. Shi
- Chemistry, Medicine
- Iranian journal of pharmaceutical research : IJPR
- 1 February 2016
To develop a new more accurate spectrophotometric method for detecting monoamine oxidase inhibitors from plant extracts, a series of amine substrates were selected and their ability to be oxidized by… Expand
Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration
- Wei Fan, X. Gao, +16 authors Yi Ting Zhou
- Biology, Medicine
- Molecular and Cellular Biology
- 1 October 2018
The regenerative process of injured muscle is dependent on the fusion and differentiation of myoblasts derived from muscle stem cells. Hsp70 is important for maintaining skeletal muscle homeostasis… Expand
Synthesis, Characterization, and Biological Evaluation of a Porphyrin-Based Photosensitizer and Its Isomer for Effective Photodynamic Therapy against Breast Cancer.
A photosensitizer with high phototoxicity, low dark toxicity, and good water solubility is crucial for effective photodynamic therapy (PDT). In this study, a novel class of porphyrin-based… Expand
Synthesis and structure–activity relationship of nuciferine derivatives as potential acetylcholinesterase inhibitors
- Zhongduo Yang, Zhuwen Song, +5 authors X. Yao
- Chemistry
- Medicinal Chemistry Research
- 3 January 2014
Acetylcholinesterase inhibitors (AChEIs) are currently the best available pharmacotherapy for Alzheimer patients, but because of bioavailability issues, there is still great interest in discovering… Expand
2‐deoxy‐D‐glucose augments photodynamic therapy induced mitochondrial caspase‐independent apoptosis and energy‐mediated autophagy
Compared to normal cells, malignant cells have a high degree of aerobic glycolysis, also known as the Warburg effect. Therefore, supplementing photodynamic therapy (PDT), an established cancer… Expand
Manipulation of Mitophagy by "All-in-One" Nanosensitizer Augments Sonodynamic Glioma Therapy.
Limited penetration of chemotherapeutic drugs through the blood brain barrier (BBB), and the increased chemo-resistance of glioma cells due to macroautophagy/autophagy, result in high tumor… Expand
Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration
- Xiao Xia Cong, X. Gao, +16 authors Yi Ting Zhou
- Chemistry, Medicine
- Cell Death & Differentiation
- 12 February 2020
Rab5 is a master regulator for endosome biogenesis and transport while its in vivo physiological function remains elusive. Here, we find that Rab5a is upregulated in several in vivo and in vitro… Expand
Two new cyclic dipeptides from Rhinocladiella sp. lgt-3, a fungal endophyte isolated from Tripterygiun wilfordii Hook
- D. Zhang, Z. Yang, Penghui Xue, K. Zhi, Y. Shi, Ming-gang Wang
- Biology, Medicine
- Natural product research
- 9 September 2014
Two new cyclic dipeptides, rhinocladin A (1) and rhinocladin B (2), were isolated from a fungal endophyte (Rhinocladiella sp. lgt-3) of Tripterygiun wilfordii Hook. Their structures were elucidated… Expand
Apoptosis and autophagy induced by DVDMs-PDT on human esophageal cancer Eca-109 cells.
- Y. Shi, B. Zhang, +7 authors K. Zhang
- Chemistry, Medicine
- Photodiagnosis and photodynamic therapy
- 1 December 2018
BACKGROUND
Esophageal cancer is a common gastrointestinal cancer. About 300,000 people die from esophageal cancer every year in the world. Photodynamic therapy (PDT) has attracted attention as a… Expand