• Publications
  • Influence
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight intoExpand
  • 2,768
  • 216
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
TGF-β signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight intoExpand
  • 4,406
  • 174
Open Access
Crystal Structure of the PTEN Tumor Suppressor Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association
The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer predisposition syndromes. PTEN is a phosphatase that can act on both polypeptide and phosphoinositide substratesExpand
  • 924
  • 88
Serine/Threonine Phosphatases: Mechanism through Structure
  • Y. Shi
  • Biology, Medicine
  • Cell
  • 30 October 2009
The reversible phosphorylation of proteins is accomplished by opposing activities of kinases and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the specificExpand
  • 990
  • 77
Open Access
Molecular mechanisms of caspase regulation during apoptosis
  • S. Riedl, Y. Shi
  • Medicine, Biology
  • Nature Reviews Molecular Cell Biology
  • 1 November 2004
Caspases, which are the executioners of apoptosis, comprise two distinct classes, the initiators and the effectors. Although general structural features are shared between the initiator and theExpand
  • 1,670
  • 73
Open Access
Structural basis of IAP recognition by Smac/DIABLO
Apoptosis is an essential process in the development and homeostasis of all metazoans. The inhibitor-of-apoptosis (IAP) proteins suppress cell death by inhibiting the activity of caspases; thisExpand
  • 797
  • 65
Mechanisms of caspase activation and inhibition during apoptosis.
  • Y. Shi
  • Medicine, Biology
  • Molecular cell
  • 1 March 2002
Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conservedExpand
  • 1,532
  • 58
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
Apoptosis (programmed cell death), an essential process in the development and homeostasis of metazoans, is carried out by caspases. The mitochondrial protein Smac/DIABLO performs a critical functionExpand
  • 796
  • 47
Crystal Structure of a Smad MH1 Domain Bound to DNA Insights on DNA Binding in TGF-β Signaling
The Smad family of proteins, which are frequently targeted by tumorigenic mutations in cancer, mediate TGF-beta signaling from cell membrane to nucleus. The crystal structure of a Smad3 MH1 domainExpand
  • 684
  • 47
Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde
The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. HAUSP, a representative UBP, specifically deubiquitinatesExpand
  • 495
  • 38