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Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.
- F. Monsma, Y. Shen, R. P. Ward, M. Hamblin, D. Sibley
- Biology, Medicine
- Molecular pharmacology
- 1 March 1993
We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to… Expand
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
- B. Roth, S. D. Craigo, +5 authors D. Sibley
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 March 1994
The authors examined the affinities of 36 typical and atypical antipsychotic agents for the cloned rat 5-hydroxytryptamine-6 (5-HT6) and rat 5-hydroxytryptamine-7 (5-HT7) receptors in transiently… Expand
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
- Y. Shen, F. Monsma, M. A. Metcalf, P. Jose, M. Hamblin, D. Sibley
- Biology, Medicine
- The Journal of biological chemistry
- 25 August 1993
We have utilized the polymerase chain reaction technique to selectively amplify a G protein-coupled receptor cDNA from rat kidney proximal convoluted tubule mRNA, which exhibits high homology with… Expand
Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)
- X. Yang, H. Jin, Xiangyu Cai, Siwei Li, Y. Shen
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 26 March 2012
Calcium influx through the Ca2+ release-activated Ca2+ (CRAC) channel is an essential process in many types of cells. Upon store depletion, the calcium sensor in the endoplasmic reticulum, STIM1,… Expand
A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy.
Mitochondrial autophagy, or mitophagy, is a major mechanism involved in mitochondrial quality control via selectively removing damaged or unwanted mitochondria. Interactions between LC3 and mitophagy… Expand
Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake
Mitochondrial calcium uptake is a critical event in various cellular activities. Two recently identified proteins, the mitochondrial Ca2+ uniporter (MCU), which is the pore‐forming subunit of a Ca2+… Expand
Molecular neurobiology of dopaminergic receptors.
Table I summarizes the properties of all of the dopamine receptors that have been cloned to date. Thus far, five different genes encoding pharmacologically distinct receptors have been identified and… Expand
Molecular Cloning of a Novel G Protein‐Coupled Receptor Related to the Opiate Receptor Family
Abstract: A cDNA clone encoding a novel G protein‐linked receptor was isolated from a rat cerebral cortex cDNA library using a polymerase chain reaction‐amplified cDNA fragment as a probe. This… Expand
Calcium‐independent calmodulin binding and two‐metal–ion catalytic mechanism of anthrax edema factor
Edema factor (EF), a key anthrax exotoxin, has an anthrax protective antigen‐binding domain (PABD) and a calmodulin (CaM)‐activated adenylyl cyclase domain. Here, we report the crystal structures of… Expand
Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling
MyD88 adaptor-like protein (Mal) is a crucial adaptor that acts as a bridge to recruit the MyD88 molecule to activated TLR4 receptors in response to invading pathogens. The specific assembly of the… Expand