• Publications
  • Influence
Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.
We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology toExpand
  • 576
  • 33
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
The authors examined the affinities of 36 typical and atypical antipsychotic agents for the cloned rat 5-hydroxytryptamine-6 (5-HT6) and rat 5-hydroxytryptamine-7 (5-HT7) receptors in transientlyExpand
  • 628
  • 27
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
We have utilized the polymerase chain reaction technique to selectively amplify a G protein-coupled receptor cDNA from rat kidney proximal convoluted tubule mRNA, which exhibits high homology withExpand
  • 468
  • 27
Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)
Calcium influx through the Ca2+ release-activated Ca2+ (CRAC) channel is an essential process in many types of cells. Upon store depletion, the calcium sensor in the endoplasmic reticulum, STIM1,Expand
  • 159
  • 27
  • Open Access
A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy.
Mitochondrial autophagy, or mitophagy, is a major mechanism involved in mitochondrial quality control via selectively removing damaged or unwanted mitochondria. Interactions between LC3 and mitophagyExpand
  • 216
  • 20
  • Open Access
Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake
Mitochondrial calcium uptake is a critical event in various cellular activities. Two recently identified proteins, the mitochondrial Ca2+ uniporter (MCU), which is the pore‐forming subunit of a Ca2+Expand
  • 91
  • 18
  • Open Access
Molecular neurobiology of dopaminergic receptors.
Table I summarizes the properties of all of the dopamine receptors that have been cloned to date. Thus far, five different genes encoding pharmacologically distinct receptors have been identified andExpand
  • 243
  • 14
Molecular Cloning of a Novel G Protein‐Coupled Receptor Related to the Opiate Receptor Family
Abstract: A cDNA clone encoding a novel G protein‐linked receptor was isolated from a rat cerebral cortex cDNA library using a polymerase chain reaction‐amplified cDNA fragment as a probe. ThisExpand
  • 231
  • 10
Calcium‐independent calmodulin binding and two‐metal–ion catalytic mechanism of anthrax edema factor
Edema factor (EF), a key anthrax exotoxin, has an anthrax protective antigen‐binding domain (PABD) and a calmodulin (CaM)‐activated adenylyl cyclase domain. Here, we report the crystal structures ofExpand
  • 116
  • 10
  • Open Access
Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling
MyD88 adaptor-like protein (Mal) is a crucial adaptor that acts as a bridge to recruit the MyD88 molecule to activated TLR4 receptors in response to invading pathogens. The specific assembly of theExpand
  • 56
  • 10