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Cytosporone B is an agonist for nuclear orphan receptor Nur77.
Nuclear orphan receptor Nur77 has important roles in many biological processes. However, a physiological ligand for Nur77 has not been identified. Here, we report that the octaketide cytosporone B… Expand
Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete.
A PCR-based screening approach led to the identification of a deep-sea-derived Streptomyces sp. SCSIO 03032 capable of producing new bisindole alkaloids spiroindimicins A-D (1-4). Structural… Expand
Enriching plant microbiota for a metagenomic library construction.
- HaoXin Wang, Zhao-Liang Geng, Ying Zeng, Y. Shen
- Biology, Medicine
- Environmental microbiology
- 1 October 2008
Plant microbiota (the microorganisms that live in any associations with plant tissues) represents a rather unexplored area of metagenomic research compared with soils and oceans. Constructing a… Expand
Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes.
- L. Lou, Guoliang Qian, +8 authors L. Du
- Chemistry, Medicine
- Journal of the American Chemical Society
- 2 February 2011
HSAF was isolated from Lysobacter enzymogenes , a bacterium used in the biological control of fungal diseases of plants. Structurally, it is a tetramic acid-containing macrolactam fused to a… Expand
Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases
A series of 12 recombinants expressing sets of polyketide synthase (PKS) genes from the whiE (Streptomyces coelicolor), sch (S. halstedii), and cur (S. curacoi) spore pigment biosynthetic gene… Expand
Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF.
Antifungal HSAF (heat-stable antifungal factor, dihydromaltophilin) is a polycyclic tetramate macrolactam from the biocontrol agent Lysobacter enzymogenes. Its biosynthetic gene cluster contains only… Expand
A Novel Ansamycin, Naphthomycin K from Streptomyces sp.
One novel ansamycin, namely naphthomycin K, together with two known naphthomycins A and E, were isolated from the commensal strain Streptomyces sp. CS of the medicinal plant Maytenus hookeri. Their… Expand
Nematicidal epipolysulfanyldioxopiperazines from Gliocladium roseum.
Five new verticillin-type epipolysulfanyldioxopiperazines, gliocladine A (1), B (2), C (3), D (4), and E (5), were isolated from wheat solid-substrate fermentation of Gliocladium roseum 1A, along… Expand
Secondary metabolites from endophytic Streptomyces aureofaciens CMUAc130 and their antifungal activity.
Received 9 November 2004 Revised 28 January 2005 Accepted 11 February 2005 Streptomyces aureofaciens CMUAc130 was isolated from the root tissue of Zingiber officinale Rosc. (Zingiberaceae). It was an… Expand
Carbohydrates from Cynanchum otophyllum.
Four new carbohydrates were isolated from the acidic hydrolysis part of the ethyl acetate extract of Cynanchum otophyllum Schneid (Asclepiadaceae). Their structures were determined as methyl… Expand