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Cytosporone B is an agonist for nuclear orphan receptor Nur77.
Nuclear orphan receptor Nur77 has important roles in many biological processes. However, a physiological ligand for Nur77 has not been identified. Here, we report that the octaketide cytosporone BExpand
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Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete.
A PCR-based screening approach led to the identification of a deep-sea-derived Streptomyces sp. SCSIO 03032 capable of producing new bisindole alkaloids spiroindimicins A-D (1-4). StructuralExpand
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Enriching plant microbiota for a metagenomic library construction.
Plant microbiota (the microorganisms that live in any associations with plant tissues) represents a rather unexplored area of metagenomic research compared with soils and oceans. Constructing aExpand
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Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes.
HSAF was isolated from Lysobacter enzymogenes , a bacterium used in the biological control of fungal diseases of plants. Structurally, it is a tetramic acid-containing macrolactam fused to aExpand
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Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases
A series of 12 recombinants expressing sets of polyketide synthase (PKS) genes from the whiE (Streptomyces coelicolor), sch (S. halstedii), and cur (S. curacoi) spore pigment biosynthetic geneExpand
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Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF.
Antifungal HSAF (heat-stable antifungal factor, dihydromaltophilin) is a polycyclic tetramate macrolactam from the biocontrol agent Lysobacter enzymogenes. Its biosynthetic gene cluster contains onlyExpand
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A Novel Ansamycin, Naphthomycin K from Streptomyces sp.
  • C. Lu, Y. Shen
  • Biology, Medicine
  • The Journal of Antibiotics
  • 1 October 2007
One novel ansamycin, namely naphthomycin K, together with two known naphthomycins A and E, were isolated from the commensal strain Streptomyces sp. CS of the medicinal plant Maytenus hookeri. TheirExpand
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Nematicidal epipolysulfanyldioxopiperazines from Gliocladium roseum.
Five new verticillin-type epipolysulfanyldioxopiperazines, gliocladine A (1), B (2), C (3), D (4), and E (5), were isolated from wheat solid-substrate fermentation of Gliocladium roseum 1A, alongExpand
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Secondary metabolites from endophytic Streptomyces aureofaciens CMUAc130 and their antifungal activity.
Received 9 November 2004 Revised 28 January 2005 Accepted 11 February 2005 Streptomyces aureofaciens CMUAc130 was isolated from the root tissue of Zingiber officinale Rosc. (Zingiberaceae). It was anExpand
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Carbohydrates from Cynanchum otophyllum.
Four new carbohydrates were isolated from the acidic hydrolysis part of the ethyl acetate extract of Cynanchum otophyllum Schneid (Asclepiadaceae). Their structures were determined as methylExpand
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