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Topoisomerase IIα, rather than IIβ, is a promising target in development of anti-cancer drugs.
The advantage of targeting TOP2 α over TOP2β and action of various agents on TOP2α is discussed, which may be an efficacious and safe chemotherapeutic target for cancer treatment. Expand
Anti-inflammatory activities of fractions from Geranium nepalense and related polyphenols.
The results showed that ethyl acetate fraction of the water extract of G. nepalense possessed significant activity at 2.5 g/kg (p < 0.01) with aspirin as a positive control, and the isolation of polyphenols provides a clue for beneficial effects of G-nepalense in the demonstrated anti-inflammatory activity. Expand
New Furans from Cirsium chlorolepis.
  • Y. Shen, Q. Mu
  • Chemistry, Medicine
  • Planta medica
  • 1 October 1990
From the roots of CIRSIUM CHLOROLEPIS (Compositae) two known compounds, 5-hydroxymethyl-2-furancarboxaldehyde, and 5-methoxymethyl-2-furan-carboxaldehyde, and two new compounds, cirsiumal-dehyde (Expand
A new phenoxazine derivative isolated from marine sediment actinomycetes, Nocardiopsis sp. 236.
During screening of marine actinomycetes for anti-mycobacterial activity, a new phenoxazine derivative (1) was isolated, along with 6-phenazinediol (2), 6-methoxy-1-phenazinol (3), nocardamin (4),Expand
New diterpene alkaloids from the roots of Spiraea japonica.
Structures of 1-3 were elucidated primarily on the basis of 1D and 2D NMR experiments. Expand
16,17-dihydroxycyclooctatin, a new diterpene from Streptomyces sp. LZ35.
Results demonstrated that gene cluster and pathway analysis are key to guided isolation of new natural products, including cyclooctatin, a new diterpene. Expand
Studies on the Constituents of Adelostemma gracillimum.
The glycone portion of the glycoside of ADELOSTEMMA GRACILLIMUM Hook. f. (Asclepiadaceae) was investigated. Three known polyoxypregnane ester-type aglycones, penupogenin ( 1) (1, 2), kidjoranine ( 2)Expand
Oxoprothracarcin, a novel pyrrolo[1,4]benzodiazepine antibiotic from marine Streptomyces sp. M10946.
A novel pyrrolo[1,4]benzodiazepine antibiotic, designated oxoprothracarcin (3), was isolated from the marine strain Streptomyces sp. M10946 along with three known secondary metabolites,Expand