• Publications
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Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory
One possibility is that lifetime cerebral metabolism associated with regionally specific default activity predisposes cortical regions to AD-related changes, including amyloid deposition, metabolic disruption, and atrophy, which may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment. Expand
Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus
It is suggested that the newly identified dorsal nexus plays a critical role in depressive symptomatology, in effect “hot wiring” networks together; it further suggests that reducing increased connectivity of the dorsal nexus presents a potential therapeutic target. Expand
Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study
Depressed patients have left amygdala hyperarousal, even when processing stimuli outside conscious awareness, and increased amygdala activation normalizes with antidepressant treatment. Expand
Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression
There was no significant correlation between hippocampal volume and age in either post-depressive or control subjects, whereas there was a significant correlation with total lifetime duration of depression, which suggests that repeated stress during recurrent depressive episodes may result in cumulative hippocampal injury as reflected in volume loss. Expand
The default mode network and self-referential processes in depression
Depression is characterized by both stimulus-induced heightened activity and a failure to normally down-regulate activity broadly within the DMN, and these findings provide a brain network framework within which to consider the pathophysiology of depression. Expand
Hippocampal atrophy in recurrent major depression.
The results suggest that depression is associated with hippocampal atrophy, perhaps due to a progressive process mediated by glucocorticoid neurotoxicity. Expand
[11C]PIB in a nondemented population
Elevated [11C]PIB binding in nondemented subjects suggests that [11 C]P IB amyloid imaging may be sensitive for detection of a preclinical Alzheimer disease state. Expand
Untreated depression and hippocampal volume loss.
Antidepressants may have a neuroprotective effect during depression and longer durations during which depressive episodes went untreated with antidepressant medication were associated with reductions in hippocampal volume. Expand
Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine.
The normalization of CSF ALLO content in depressed patients appears to be sufficient to mediate the anxiolytic and antidysphoric actions of fluoxetine or fluvoxamine via its positive allosteric modulation of GABA type A receptors. Expand
Neuroimaging studies of mood disorder effects on the brain
  • Y. Sheline
  • Medicine, Psychology
  • Biological Psychiatry
  • 1 August 2003
Mechanisms proposed to explain volume loss in depression include glucocorticoid neurotoxicity, decreased brain-derived growth factor, decreased neurogenesis, and loss of plasticity. Expand