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Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study
TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described. Expand
Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study
  • Yuan Yu, Dan Xu, +26 authors Y. Shang
  • Medicine
  • Critical Care
  • 14 May 2020
TLDR
Critically ill patients with COVID-19 are associated with a higher risk of severe complications and need to receive an intensive level of treatments, and these patients are investigated in a multicenter prospective observational study. Expand
Thrombocytopenia and its association with mortality in patients with COVID‐19
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which causes novel coronavirus disease 2019 (COVID‐19), is spreading rapidly around the world. Thrombocytopenia in patients with COVID‐19Expand
Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19
TLDR
Untargeted metabolomic and lipidomic analyses of plasma from a cohort of COVID-19 patients who had experienced different symptoms found the metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of CO VID-19 affected patient metabolism. Expand
Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China
TLDR
Front-line experts in China fighting against the COVID-19 epidemic in Wuhan were organized to develop an expert statement to provide trustworthy recommendation on the management of critically ill CO VID-19 patients, with a strong agreement from voting participants. Expand
DAPK1–p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death
TLDR
The DAPK1–p53 interaction is a signaling point of convergence of necrotic and apoptotic pathways and is a desirable target for the treatment of ischemic insults. Expand
NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies
TLDR
A series of promising therapeutic approaches that target theNLRP3 inflammasome signaling including anti-IL-1 therapy, small molecule NLRP3 inhibitors and other compounds are reviewed, however, these approaches are still experimental in neurological diseases. Expand
Tracheostomy in the COVID-19 era: global and multidisciplinary guidance
TLDR
By synthesising early experiences from countries that have managed a surge in patient numbers, emerging virological data, and international, multidisciplinary expert opinion, this work aims to provide consensus guidelines and recommendations on the conduct and management of tracheostomy during the COVID-19 pandemic. Expand
Erythropoietin prevents PC12 cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis via the Akt/GSK-3β/caspase-3 mediated signaling pathway
TLDR
It is demonstrated that exposure of PC12 cells to 1-methyl-4-phenylpyridinium ion (MPP+) with recombinant human EPO, significantly decreased apoptosis as measured by TUNEL and caspase-3 activity when compared to MPP+ treatment alone. Expand
Antioxidant effect of erythropoietin on 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cells.
TLDR
The results show that erythropoietin may provide a useful therapeutic strategy for the treatment of oxidative stress-induced neurodegenerative diseases such as Parkinson disease. Expand
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