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Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall.
  • T. Hùng, M. Na, +5 authors K. Bae
  • Chemistry, Medicine
  • Journal of ethnopharmacology
  • 24 November 2006
TLDR
Results suggested that Dipsacus asper due to its antioxidant constituents, 1-6, may have a role to play in preventing the development and progression of atherosclerotic disease. Expand
Green tea catechins as a BACE1 (β-secretase) inhibitor
In the course of searching for BACE1 (beta-secretase) inhibitors from natural products, the ethyl acetate soluble fraction of green tea, which was suspected to be rich in catechin content, showedExpand
Protective effects of fangchinoline and tetrandrine on hydrogen peroxide-induced oxidative neuronal cell damage in cultured rat cerebellar granule cells.
TLDR
FAN and TET may mitigate the harmful effects of H2O2 -induced neuronal cell death by interfering with the increase of [Ca 2+] c, and then by inhibiting glutamate release and generation of ROS. Expand
Aralia cordata protects against amyloid beta protein (25-35)-induced neurotoxicity in cultured neurons and has antidementia activities in mice.
TLDR
Oleanolic acid isolated from A. cordata inhibited neuronal death, elevation of [Ca(2+)](i), glutamate release, and generation of ROS induced by Abeta(25-35) in cultured rat cortical neurons, suggesting that the neuroprotective effect of A. Cordata may be, at least in part, attributable to this compound. Expand
Anti-inflammatory activity of flavonoids fromPopulus davidiana
Anin vitro bioassay-guide revealed that the methanol (MeOH) extract of the stem bark ofPopulus davidiana showed considerable inhibitory activity against cyclooxygenase (COX-1, COX-2). ContinuousExpand
Cytotoxic and COX-2 inhibitory constituents from the aerial parts ofAralia cordata
TLDR
All isolated compounds were evaluated for their cytotoxicity against L 1210, K562, and LLC tumor cell lines using MTT assay and most compounds, except for 2, 10, and12, showed a strong inhibitory activity against COX-1, while most compounds exhibited a moderate or weak inhibitoryActivity againstCOX-2. Expand
Polygalae radix extract protects cultured rat granule cells against damage induced by NMDA.
TLDR
It is suggested that PR prevents NMDA-induced neuronal cell damage in vitro. Expand
Phenolic glycosides with antioxidant activity from the stem bark of Populus davidiana.
Phytochemical study on the EtOAc-soluble fraction of the stem bark of Populus davidiana resulted in the isolation of 10 phenolic glycosides (1-10), which were identified on the basis ofExpand
Neuroprotective effect of Smilacis chinae rhizome on NMDA-induced neurotoxicity in vitro and focal cerebral ischemia in vivo.
TLDR
The results suggest that the neuroprotective effect of SCR against focal cerebral ischemic injury is due to its anti-excitotoxic effects and that SCR may have a therapeutic role in neurodegenerative diseases such as stroke. Expand
β-secretase (BACE1)-inhibiting stilbenoids from Smilax Rhizoma
In the course of searching for BACE1 (beta-secretase) inhibitors from natural products, the ethyl acetate soluble fraction of Smilax Rhizoma (the dried rhizomes of Smilax china L.) showed potentExpand
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