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Composition of pulp, skin and seeds of prickly pears fruit (Opuntia ficus indica sp.)
- R. L. El Kossori, C. Villaume, E. El Boustani, Y. Sauvaire, L. Méjean
- Biology, MedicinePlant foods for human nutrition
The proximate composition of pulp, skin and seeds of prickly pear cactus was investigated and is reported on a dry weight basis and the most abundant component was ethanol-soluble carbohydrates.
4-Hydroxyisoleucine: A Novel Amino Acid Potentiator of Insulin Secretion
4-hydroxyisoleucine insulinotropic activity might, at least in part, account for fenugreek seeds' antidiabetic properties and may be considered as a novel drug with potential interest for the treatment of NIDDM.
Nigella sativa seed extracts enhance glucose‐induced insulin release from rat‐isolated Langerhans islets
- H. Rchid, H. Chevassus, +4 authors Y. Sauvaire
- Biology, MedicineFundamental & clinical pharmacology
- 1 October 2004
The data show that the antidiabetic properties of N. sativa seeds may be, at least partly, mediated by stimulated insulin release, and that the basic subfraction largely contributes to this stimulatory effect.
Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek
It appears that saponins may be implicated, alone or together with diosgenin, in the observed hypocholesterolemic effect of fenugreek seeds in diabetic dogs.
Steroid saponins from fenugreek seeds: Extraction, purification, and pharmacological investigation on feeding behavior and plasma cholesterol
It is shown that steroid saponins enhance food consumption and motivation to eat, and reduce plasma cholesterol levels in rats, which resulted in a progressive weight gain in these animals, in contrast to untreated diabetic controls.
Effects of a fenugreek seed extract on feeding behaviour in the rat: Metabolic-endocrine correlates
- P. Petit, Y. Sauvaire, G. Ponsin, M. Manteghetti, A. Fave, G. Ribes
- MedicinePharmacology Biochemistry and Behavior
- 1 June 1993
Investigation of the effects of a fenugreek seed extract on feeding behaviour in rats found it enhances food consumption and motivation to eat in rats and also induces hyperinsulinemia as well as hypocholesterolemia.
4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties.
- C. Broca, R. Gross, +6 authors G. Ribes
- MedicineAmerican journal of physiology. Endocrinology and…
- 1 October 1999
In non-insulin-dependent diabetic (NIDD) rats, a single intravenous administration of 4-OH-Ile partially restored glucose-induced insulin response without affecting glucose tolerance; a 6-day subchronic administration of4-OH -Ile reduced basal hyperglycemia, decreased basal insulinemia, and slightly, but significantly, improved glucose tolerance.
Antidiabetic Effects of Subtractions from Fenugreek Seeds in Diabetic Dogs
- G. Ribes, Y. Sauvaire, C. D. Costa, J. Baccou, M. Loubatières-Mariani
- MedicineProceedings of the Society for Experimental…
- 1 June 1986
The results show that the antidiabetic properties of fenugreek seeds are contained in the testa and endosperm, which is not possible to exclude the existence of one or more unknown active pharmacological compounds in this subfraction of the seed.
4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion.
- C. Broca, M. Manteghetti, +5 authors G. Ribes
- Biology, MedicineEuropean journal of pharmacology
- 3 March 2000
The insulinotropic properties of 4-hydroxyisoleucine, in the micromolar range, are seen only in the presence of the linear major isoform; they also require carbon alpha in S-configuration, full methylation and carbon gamma-hydroxylation.
Comparison of effects of prickly pear (Opuntia ficus indica sp) fruit, arabic gum, carrageenan, alginic acid, locust bean gum and citrus pectin on viscosity and in vitro digestibility of casein
The results suggest that the decrease in N release in the digestion cell model is due to the interaction of the fibres with the enzymes or casein rather than to the apparent viscosity of the mixtures.