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High Frequency of Mutations of the PIK3CA Gene in Human Cancers
Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell proliferation, adhesion, survival, and motility ([ 1 ]–[ 3 ]).… Expand
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
PIK3CA is mutated in diverse human cancers, but the functional effects of these mutations have not been defined. To evaluate the consequences of PIK3CA alterations, the two most common mutations were… Expand
Genomic Classification of Cutaneous Melanoma
We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a… Expand
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated in human breast carcinomas is through loss of ASPP activity. We have… Expand
Colorectal cancer: Mutations in a signalling pathway
Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal… Expand
Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer
Tumors harbor mutations that disrupt chromatid separation during cell division, leading to chromosomal abnormalities. Most cancer cells are characterized by aneuploidy, an abnormal number of… Expand
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4
Tyrosine phosphorylation is important in signaling pathways underlying tumorigenesis. We performed a mutational analysis of the protein tyrosine kinase (PTK) gene family in cutaneous metastatic… Expand
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
PIK3CA, one of the two most frequently mutated oncogenes in human tumors, codes for p110alpha, the catalytic subunit of a phosphatidylinositol 3-kinase, isoform alpha (PI3Kalpha, p110alpha/p85).… Expand
Mining Exomic Sequencing Data to Identify Mutated Antigens Recognized by Adoptively Transferred Tumor-reactive T cells
Substantial regressions of metastatic lesions have been observed in up to 70% of patients with melanoma who received adoptively transferred autologous tumor-infiltrating lymphocytes (TILs) in phase 2… Expand
The PIK3CA gene is mutated with high frequency in human breast cancers
The phosphatidylinositol 3-kinases (PI3Ks) are known regulators of cellular growth and proliferation. It has recently been reported that somatic mutations within the PI3K subunit p110? (PIK3CA) are… Expand