Y. Saga

Publications235
h-index65
Citations14,806
Highly Influential Citations1,011
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MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube.
TLDR
It is strongly suggested that MesP1 is expressed in the heart tube precursor cells and is required for mesodermal cells to depart from the primitive streak and to generate a single heart tube.
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Conserved Role of nanos Proteins in Germ Cell Development
TLDR
Although mice and flies differ in their mechanisms for germ cell specification, there seems to be conserved function for nanos proteins among invertebrates and vertebrates.
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Nanos2 suppresses meiosis and promotes male germ cell differentiation.
TLDR
It is shown that Nanos2 plays critical roles in the differentiation of male germ cells and maintains the suppression of meiosis by preventing Stra8 expression, which is required for premeiotic DNA replication, after Cyp26b1 is decreased.
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An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation
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Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors.
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Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.
TLDR
It is suggested that MesP2 controls sclerotomal polarity by regulating the signaling systems mediated by notch-delta and FGF, which are essential for segmentation.
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Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice
TLDR
It is suggested the possibility that active repression of an essential enzyme and subsequent unique cellular dynamics ensures successful implementation of genome-wide epigenetic reprogramming in migrating PGCs.
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The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity
TLDR
Ex vivo levels of Notch1 activity in mice are visualized, showing that it oscillates in the posterior PSM but is arrested in the anterior PSM, and it is proposed that the oscillation of notch activity is arrested and translated in the wavefront by Mesp2.
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Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites.
TLDR
Zebrafish mesp genes are involved in anteroposterior specification within the presumptive somites, by regulating the essential signalling pathways mediated by Notch-Delta and FGFR.
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MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation.
TLDR
The amino acid sequence and its expression pattern suggest that MesP1 plays an important role in the development of the nascent mesoderm including PGC, which is similar to that of PGC detected by the alkaline phosphatase activity.
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