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Natural occurrence and clastogenic effects of nivalenol, deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, and zearalenone in corn from a high-risk area of esophageal cancer.
TLDR
High levels of trichothecenes in food may possibly be associated with esophagitis and esophageal cancer in Linxian, China, and Cytotoxic effects were observed at slightly higher concentrations.
Mutagenicity studies of benzidine and its analogs: structure-activity relationships.
TLDR
Physicochemical parameters of these compounds including oxidation potentials, the energy difference between the lowest unoccupied molecular orbital and the highest occupied molecular orbital, ionization potentialS, dipole moment, relative partition coefficient, and basicity did not correlate with their bacterial mutagenic activities.
Effects of the nitro‐group on the mutagenicity and toxicity of some benzamines
TLDR
Cytotoxicity testing with Chinese hamster ovary cells showed that the presence of the nitro‐group in these compounds had no specific effect on toxicity, and the mutagenicity and toxicity of these compounds were not related to physico‐chemical properties.
Effects of 2-hydroxypropyl-beta-cyclodextrin on pharmacokinetics of digoxin in rabbits and humans.
TLDR
The pharmacokinetic results from the rabbit study were similar to human studies and no significant difference was observed for AUC, Cmax and Tmax, and HPCD based oral digoxin solution could serve as an alternative to tablets.
Mutagenicity and induction of drug-metabolizing enzyme activity by LPG combustion particulates in rats.
TLDR
It was seen that AHH was more sensitive than GST to induction by the extracts, which showed mutagenicity for Salmonella typhimurium strain TA98 and its derivatives TA98NR and TA98/1,8-DNP6 with or without S9 mix.
[Trichothecenes in staple food from a high-incidence area of carcinoma of the esophagus and gastric cardia and their carcinogenic potential].
TLDR
It is first demonstrated that the extracts of corn from esophageal cancer patients' families and their NIV and DON fractions purified by HPLC could induce significant chromosome aberrations in V79 cells, indicating that they had carcinogenic potential.