• Publications
  • Influence
Ubiquitin ligase CHIP induces TRAF2 proteasomal degradation and NF‐κB inactivation to regulate breast cancer cell invasion
Transcriptional factor nuclear factor‐kappaB (NF‐κB) plays a crucial role in human breast cancer cell invasion and metastasis. The carboxyl terminus of Hsc70‐interacting protein (CHIP) is aExpand
  • 54
  • 8
Expression and characterization of a novel enantioselective lipase from Acinetobacter species SY-01.
A novel lipase gene, lipase A, of Acinetobacter species SY-01 (A. species SY-01) was cloned, sequenced, and expressed in Bacillus subtilis 168. The deduced amino acid (aa) sequences for the lipase AExpand
  • 38
  • 7
  • PDF
The crystal structure of an Fe-superoxide dismutase from the hyperthermophile Aquifex pyrophilus at 1.9 A resolution: structural basis for thermostability.
Superoxide dismutase (SOD) from Aquifex pyrophilus, a hyperthermophilic bacterium, is an extremely heat-stable enzyme that maintains about 70% of its activity after heat treatment for 60 minutes atExpand
  • 109
  • 6
Structure-based identification of a novel NTPase from Methanococcus jannaschii
Almost half of the entire set of predicted genomic products from Methanococcus jannaschii are classified as functionally unknown hypothetical proteins. We present a structure-based identification ofExpand
  • 118
  • 6
Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult.
OBJECTIVE To comparatively evaluate selected herbs for their ability to protect neuronal cells from direct betaA(1-42) insult. DESIGN Twenty-seven (27) herbs were selected, extracted with aqueousExpand
  • 75
  • 4
  • PDF
Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation.
The mechanism of acacetin-induced apoptosis of human breast cancer MCF-7 cells was investigated. Acacetin caused 50% growth inhibition (IC50) of MCF-7 cells at 26.4% 0.7% M over 24 h in the MTTExpand
  • 114
  • 3
  • PDF
Cloning and expression of superoxide dismutase from Aquifex pyrophilus, a hyperthermophilic bacterium
A superoxide dismutase (SOD) gene of Aquifex pyrophilus, a marine hyperthermophilic bacterium, was cloned, sequenced, expressed in Escherichia coli, and its gene product characterized. This is theExpand
  • 32
  • 3
A versatile endonuclease IV from Thermus thermophilus has uracil-excising and 3'-5' exonuclease activity.
Apurinic/apyrimidinic (AP) sites arise in DNA through the spontaneous loss of bases or through the release of damaged bases from DNA by DNA glycosylases. AP sites in DNA can be catalyzed by APExpand
  • 4
  • 2
Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase.
Ribosomal protein S3 (rpS3) is a multifunctional protein involved in translation, DNA repair, and apoptosis. The relationship between rpS3 and cyclin-dependent kinases (Cdks) involved in cell cycleExpand
  • 17
  • 2
  • PDF
Thermostable hydantoinase from a hyperthermophilic archaeon, Methanococcus jannaschii
A hyperthermophilic hydantoinase from Methanococcus jannaschii with an optimum growth at 85°C was cloned and expressed in E. coli. The recombinant hydantoinase was purified by affinity andExpand
  • 11
  • 2