• Publications
  • Influence
Transplantation of human bone marrow mesenchymal stem cells as a thin subretinal layer ameliorates retinal degeneration in a rat model of retinal dystrophy.
It is suggested that transplantation of hBM-MSCs as a thin subretinal layer enhances the therapeutic effect and the safety of cell transplantation. Expand
Visual acuity loss and clinical observations in a large series of patients with Stargardt disease.
Survival analysis showed that the prognosis of patients who initially were seen with visual acuity of 20/40 or better is related to age at initial visit, and this result, based on the log rank statistic, was independent of age group atInitial visit. Expand
Treatment with 9-cis β-carotene-rich powder in patients with retinitis pigmentosa: a randomized crossover trial.
Treatment with 9-cis β-carotene significantly increased retinal function in patients withRP under the tested conditions and may represent a new therapeutic approach for some patients with RP. Expand
Cone-rod dystrophy and a frameshift mutation in the PROM1 gene
The mutation described in this report further expands the clinical spectrum of PROM1 mutations and is characterized by severe visual impairment evident in the first decade of life. Expand
Mutations in C8orf37, encoding a ciliary protein, are associated with autosomal-recessive retinal dystrophies with early macular involvement.
Using homozygosity mapping in an individual with autosomal-recessive RP from a consanguineous family, three sizeable homozygous regions are identified, together encompassing 46 Mb, which underline the importance of disrupted ciliary processes in the pathogenesis of retinal dystrophies. Expand
Primary cataract extraction and intraocular lens implantation in penetrating ocular trauma.
Primary implantation of posterior chamber lenses after penetrating ocular trauma is associated with favorable visual outcome and a low rate of postoperative complications. Expand
Treatment of a retinal dystrophy, fundus albipunctatus, with oral 9-cis-β-carotene
Oral treatment with 9-cis-β-carotene led to reversal of a human retinal dystrophy and this potential therapy is readily available and should be evaluated inretinal dystrophies of similar mechanisms such as various types of retinitis pigmentosa. Expand
Clinical characteristics of rod and cone photoreceptor dystrophies in patients with mutations in the C8orf37 gene.
PURPOSE To provide the clinical features in patients with retinal disease caused by C8orf37 gene mutations. METHODS Eight patients--four diagnosed with retinitis pigmentosa (RP) and four withExpand
Short-term inter-visit variability of erg amplitudes in normal subjects and patients with retinitis pigmentosa.
It is suggested that a percentage of patients with RP with appreciably lower baseline ERG amplitudes may manifest greater inter-visit ERG amplitude variability than patients withRP with higher baseline amplitudes or controls. Expand
Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system
It is reported that conditional targeted disruption of the murine NBS1 gene in the CNS results in mal-development, degeneration, disorganization and dysfunction of the Murine visual system, especially in the optic nerve. Expand