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Pattern of Pax7 expression during myogenesis in the posthatch chicken establishes a model for satellite cell differentiation and renewal
The distinctions in Pax7 and myogenin expression patterns indicate that while some of the myoblasts differentiate and fuse into myofibers during early stages of posthatch growth, others retain their reserve cell capacity. Expand
Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip
It is shown that a wide range of tissue stem/progenitor cells contribute towards the restoration of the mouse distal digit, demonstrating that tissue stem cells rather than pluripotent blastema cells are an evolutionarily conserved cellular mode for limb regeneration after amputation. Expand
Identification and isolation of a dermal lineage with intrinsic fibrogenic potential
Fibroblasts in fibrosis Excess fibrous connective tissue, similar to scarring, forms during the repair of injuries. Fibroblasts are known to be involved, but their role is poorly characterized.Expand
In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration.
Long-term in vivo genetic lineage tracing and clonal analysis of individual cells from kidneys undergoing development, maintenance, and regeneration demonstrate that fate-restricted precursors functioning as unipotent progenitors continuously maintain and self-preserve the mouse kidney throughout life. Expand
Systemic Bud Induction and Retinoic Acid Signaling Underlie Whole Body Regeneration in the Urochordate Botrylloides leachi
It is found that retinoic acid (RA) regulates diverse developmental aspects in whole body regeneration in the colonial urochordate Botrylloides leachi, suggesting that RA signaling may have had ancestral roles in body restoration events. Expand
Vasa and the germ line lineage in a colonial urochordate.
It is demonstrated that the BS-Vasa mRNA and protein are not expressed exclusively in germ cell lineages, but appeared in cells repeatedly emerging de novo in the colony, independently of its sexual state, suggesting germ cell neogenesis (somatic embryogenesis) in B. schlosseri. Expand
Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature
Using a genetic lineage tracing approach, it is shown that embryonic and adult mesothelium represents a common lineage to trunk FSMCs, and trunk vasculature, with minimal contributions from neural crest, or circulating cells. Expand
Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells
Functional studies in vitro and in vivo confirmed that ROR2+ cells produce mesoderm progeny, APA+ cells generate syncytiotrophoblasts and CD87+ cells give rise to vasculature. Expand
Piwi positive cells that line the vasculature epithelium, underlie whole body regeneration in a basal chordate.
It is shown that WBR develops through activation, mobilization and expansion of 'dormant' cells which normally line the internal vasculature epithelium of blood vessels, and recurrent activation of Piwi(+) cells in response to developmental, physiological and environmental insults may have enabled the adaptation of colonial tunicates to the imposed varied conditions in the marine, shallow water environment. Expand
Identification of the endostyle as a stem cell niche in a colonial chordate.
The Botryllus' endostyle region is defined as an adult somatic stem cell niche by using in vivo cell labeling, engraftment, confocal microscopy, and time-lapse imaging to identify cells with stemness capabilities in the anterior ventral region of the Botrylla schlosseri. Expand