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Short Enantioselective Total Syntheses of Cheloviolenes A and B and Dendrillolide C via Convergent Fragment Coupling Using a Tertiary Carbon Radical.
The development of a convergent fragment coupling strategy for the enantioselective total syntheses of a group of rearranged spongian diterpenoids that harbor the
Novel catalyst system for hydrostannation of alkynes.
A catalyst system was developed for the highly regio- and stereoselective hydrostannation of a range of alkynes with tributylstannane under mild conditions. The active catalytic species was generated
A Ru catalyzed divergence: oxidative cyclization vs cycloisomerization of bis-homopropargylic alcohols.
  • B. Trost, Y. Rhee
  • Chemistry
    Journal of the American Chemical Society
  • 22 February 2002
TLDR
The utility of the cycloisomerization to dihydropyrans is demonstrated by an iterative process leading to the antiviral agent narbosine B and a rationale for this dramatic switch by simple ligand modification is proposed.
Callipeltoside a: total synthesis, assignment of the absolute and relative configuration, and evaluation of synthetic analogues.
TLDR
The total synthesis of the novel antitumor agent callipeltoside A, as well as several analogues, is accomplished and allows assignment of the stereochemistry not previously established and the excellent chemo- and regioselectivity highlights the synthetic potential of this new ruthenium catalyzed process.
A Rh(I)-catalyzed cycloisomerization of homo- and bis-homopropargylic alcohols.
  • B. Trost, Y. Rhee
  • Chemistry
    Journal of the American Chemical Society
  • 31 May 2003
TLDR
Rhodium catalysts demonstrate the best chemoselectivity and turnover numbers to date, and a mechanism to account for the different selectivity of this catalyst as compared to others is proposed.
Stereodefined N,O-acetals: Pd-catalyzed synthesis from homopropargylic amines and utility in the flexible synthesis of 2,6-substituted piperidines.
TLDR
A conceptually new synthetic strategy which exploits the stereochemical information of labile acyclic N,O-acetals to give an access to 2,6-disubstituted piperidines with stereochemical flexibility is developed.
Versatile Construction of 6-Substituted cis-2,8-Dioxabicyclo[3.3.0]octan-3-ones: Short Enantioselective Total Syntheses of Cheloviolenes A and B and Dendrillolide C.
TLDR
A short enantioselective synthesis of 6-substituted cis-2,8-dioxabicyclo[3.3.0]octan-3-ones is described, which is applied toward scalable 14-15 step syntheses of three rearranged spongian diterpenoids: cheloviolenes A and B and dendrillolide C.
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