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Cytocidal effect of gossypol on cultured murine erythroleukemia cells is prevented by serum protein.
These studies demonstrate that G, at pharmacologically relevant concentrations, is cytocidal for MELC and serum protein, e.g., albumin, can reduce both the cytOCidal effects of G and the uptake of [14C]G by M ELC. Expand
Adenylate cyclase activity, membrane fluidity and fatty acid composition of rat heart in essential fatty acid deficiency.
The results suggest that the changes induced by EFA deficiency in the acyl group composition of membrane phospholipids and in the number of beta-adrenergic receptors may be important in regulating adenylate cyclase activity in the heart. Expand
Anti-fertility and other actions of gossypol analogues.
It is concluded that the carbonyl groups of gossypol are needed for inhibition of erythrocyte anion transport and the hydroxy groups affect but are not essential to that inhibition. Expand
Effect of Cholesterol Feeding on Membrane Fluidity, (Na+ + K+)ATPase, Adenylate Cyclase, [3H]-Ouabain-, and [3H]-Dihydroalprenolol-binding in Rat Submandibular Salivary Glands
The effects of cholesterol feeding on the activities of (Na+ + K+)ATPase and adenylate cyclase, and on [ 3H]-ouabain and [3H]-dihydroalprenolol (DHA) binding in the rat SMSG are reported in the present communication. Expand
Further evaluation of bimolane and analogs as potential antitumor agents.
The antitumor activities of three new analogs were compared with bimolane, ICRF-154 and razoxane against four rodent tumors and, in general, bIMolane was most effective. Expand
[3H]-forskolin binding sites in rat submandibular salivary glands.
Specific [3H]-forskolin binding was linear as a function of the membrane protein concentration and reached steady-state by 30-40 min of incubation at 37 degrees C, and the bound radioligand could be readily dissociated by an excess of unlabelled forskolin. Expand
Forskolin- and dihydroalprenolol (DHA) binding sites and adenylate cyclase activity in heart of rats fed diets containing different oils
The purpose of the present investigation was to determine if dietary lipids can induce changes in the adenylate cyclase system in rat heart. Three groups of male young Sprague-Dawley rats were fedExpand
[Drug screening with the cotton-rat model of filariasis (author's transl)].
Study on the relationship between the structure and functions of anti-human cervical cancer single-chain antibody and the lengths of linkers.
The optimum length of linker of anti-human CC single-chain antibody was n = 3 from the point of mathematical modeling and biology experiments, and provided new ideas for the design and constructions of single- chain antibody, and theoretical basis for the treatment of CC. Expand
[Antineoplastic action and toxicity of probimane and its effect on immunologic functions in mice].
Probimane(AT-2153, MST-02), dlbis(4-morpholinomethyl-3,5-dioxopiperazin-1-yl) propane, exhibited good antitumor activities against S 37,L 1210, L 615, brain tumor B 22 and hepatoma HCS. The 50%Expand