• Publications
  • Influence
The genetics of keratoconus.
  • Y. Rabinowitz
  • Medicine
    Ophthalmology clinics of North America
  • 1 December 2003
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus
TLDR
A meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance showed that 2 CCT-associated loci conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls.
Keratoconus and corneal ectasia after LASIK.
From Gordon Binder Weiss Vision Institute, San Diego, Calif (Binder); Minnesota Eye Consultants, Minneapolis, Minn (Lindstrom); Emory University, Atlanta, Ga (Stulting); Ophthalmic Consultants of
Videokeratographic indices to aid in screening for keratoconus.
  • Y. Rabinowitz
  • Medicine
    Journal of refractive surgery
  • 1 September 1995
Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies.
TLDR
Analysis of single-nucleotide polymorphisms in the LOX gene provided strong genetic evidence that LOX variants lead to increased susceptibility to developing of keratoconus.
Computer-assisted corneal topography in keratoconus.
TLDR
Using a computer-assisted video-keratoscope, the topographic findings of 14 eyes of 10 patients with keratoconus were determined and two patterns commonly seen included inferior steepening more prominent temporally, and central steepening with a superimposed asymmetric bowtie pattern.
Genetic epidemiological study of keratoconus: evidence for major gene determination.
TLDR
Strong evidence of familial aggregation is observed in KC and its subclinical indices and this aggregation is likely due to a major gene effect.
Higher order wavefront aberrations and topography in early and suspected keratoconus.
TLDR
Although both vertical coma and the Inferior-Superior (I-S) topographic value were useful for distinguishing among the three study groups, a combination of wavefront aberrometry and videokeratography appears to be the most sensitive way for distinguishing between normal eyes, eyes with suspected keratoconus, and eyes with early keratconus.
A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries.
TLDR
Findings suggest SNP rs4954218, located near the RAB3GAP1 gene, previously reported to be associated with corneal malformation, is a potential susceptibility locus for keratoconus.
...
...