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Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats.
Immunocompetent cells infiltrate the kidney in several models of experimental hypertension. We have previously shown that reduction of this infiltrate results in prevention of salt-sensitiveExpand
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Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure.
BACKGROUND Interstitial mononuclear cell infiltration is a feature of experimental models of salt-sensitive hypertension (SSHTN). Since several products of these cells are capable of modifying localExpand
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Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats.
Several studies have demonstrated that treatment with antioxidants improves hypertension in spontaneously hypertensive rats (SHR). Because our laboratory has shown that renal infiltration of immuneExpand
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Renal angiotensin II concentration and interstitial infiltration of immune cells are correlated with blood pressure levels in salt-sensitive hypertension.
Renal immune cell infiltration and cells expressing angiotensin II (AII) in tubulointerstitial areas of the kidney are features of experimental models of salt-sensitive hypertension (SSHTN). AExpand
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Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.
The progressive deterioration of renal function and structure resulting from renal mass reduction are mediated by a variety of mechanisms, including oxidative stress and inflammation. Melatonin, theExpand
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Suppression of renin-angiotensin gene expression in the kidney by paricalcitol.
The renal renin-angiotensin system plays a major role in determining the rate of chronic renal disease progression. Treatment with activators of the vitamin D receptor retards the progression ofExpand
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Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition.
Recent studies have suggested that subtle microvascular and tubulointerstitial injury in the kidney can cause salt-sensitive hypertension. To test this hypothesis, we determined whether the mildExpand
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Overload proteinuria is followed by salt-sensitive hypertension caused by renal infiltration of immune cells.
Recent evidence suggests that salt-sensitive hypertension develops as a consequence of renal infiltration with immunocompetent cells. We investigated whether proteinuria, which is known to induceExpand
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Intra-Renal Angiotensin II/AT1 Receptor, Oxidative Stress, Inflammation, and Progressive Injury in Renal Mass Reduction
Significant reduction of renal mass triggers a chain of events that result in glomerular hypertension/hyperfiltration, proteinuria, glomerulosclerosis, tubulointerstitial injury, and end-stage renalExpand
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Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage.
BACKGROUND Chronic renal disease is associated with oxidative stress and reduced nitric oxide availability which, in turn, promotes hypertension and further progression of renal damage. Most actionsExpand
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