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Engineering Dendritic-Cell-Based Vaccines and PD-1 Blockade in Self-Assembled Peptide Nanofibrous Hydrogel to Amplify Antitumor T-Cell Immunity.
Dendritic cells (DCs) are increasingly used in cancer vaccines due to their ability to regulate T-cell immunity. Major limitations associated with the present DC adoptive transfer immunotherapy are… Expand
Extended-Maxima Transform Watershed Segmentation Algorithm for Touching Corn Kernels
We propose an improved watershed segmentation algorithm based on the extended-maxima transform that solves the problem of oversegmentation of touching corn kernels. Expand
Dual actions of Netrin-1 on islet insulin secretion and immune modulation.
Netrin-1 is typically known as a neural guidance cue, which has been implicated in pancreas development. Since regenerative, angiogenic and anti-inflammatory properties of Netrin-1 have been reported… Expand
Dendritic Cells Pulsed with Exosomes in Combination with PD-1 Antibody Increase the Efficacy of Sorafenib in Hepatocellular Carcinoma Model12
- Shengbin Shi, Q. Rao, Chuangnian Zhang, Xiuyuan Zhang, Y. Qin, Zuo-xing Niu
- Translational oncology
- 28 January 2018
Advanced hepatocellular carcinoma (HCC) has limited therapeutic options. Immunotherapy is a promising treatment, while sorafenib is a first-line drug-based treatment for advanced HCC. However, the… Expand
The regeneration of macro-porous electrospun poly(ɛ-caprolactone) vascular graft during long-term in situ implantation.
- Y. Wu, Y. Qin, +4 authors D. Kong
- Materials Science, Medicine
- Journal of biomedical materials research. Part B…
- 1 May 2018
Long-term evaluation of vascular grafts is an essential step to facilitate clinical translation. In this study, we investigate the long-term performance of a macro-porous poly(ɛ-caprolactone) (PCL)… Expand
Nonglutaraldehyde Fixation for off the Shelf Decellularized Bovine Pericardium in Anticalcification Cardiac Valve Applications.
- J. Liu, Huimin Jing, +5 authors Z. Wang
- Medicine, Chemistry
- ACS biomaterials science & engineering
- 30 January 2019
In valvular replacement surgery, especially in the construction of bioprosthetic valves with decellularized pericardial xenograft, glutaraldehyde (GA) is routinely utilized as the golden standard… Expand
Co-delivery of doxorubicin and pheophorbide A by pluronic F127 micelles for chemo-photodynamic combination therapy of melanoma.
- Chuangnian Zhang, Jimin Zhang, +7 authors D. Kong
- Chemistry, Medicine
- Journal of materials chemistry. B
- 23 May 2018
Combined chemotherapy and photodynamic therapy (PDT) is a promising strategy to enhance the anticancer efficacy of both drugs via combination effects. In this work, doxorubicin (DOX)-loaded… Expand
The surrounding tissue contributes to smooth muscle cells' regeneration and vascularization of small diameter vascular grafts.
Small diameter vascular grafts have been promising substitutes for bypass surgery to treat cardiovascular disease. However, no ideal product is available in the clinic. In order to design improved,… Expand
Curcumin-crosslinked acellular bovine pericardium for the application of calcification inhibition heart valves.
Glutaraldehyde (GA) crosslinked bovine or porcine pericardium tissues exhibit high cell toxicity and calcification in the construction of bioprosthetic valves, which accelerate the failure of valve… Expand
[Status of non-steroidal anti-inflammatory drugs use in areas with a high incidence of upper gastrointestinal cancer in China: a multi-center cross-sectional survey].
- S. Xie, R. Chen, +15 authors W. W. Wei
- Zhonghua yu fang yi xue za zhi [Chinese journal…
- 6 November 2019
Objective: To describe the status of non-steroidal anti-inflammatory drugs (NSAIDs) use in areas with a high incidence of upper gastrointestinal cancer in China. Methods: This study was based on the… Expand