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Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia
The present study evaluated autophagy activation in astrocytes and its contribution to astrocyte injury induced by cerebral ischemia and hypoxia. Focal cerebral ischemia was induced by permanent… Expand
A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia
TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis and increases the flow of pentose phosphate pathway (PPP), which generates NADPH and pentose. We hypothesized that TIGAR… Expand
Combined NADPH and the NOX inhibitor apocynin provides greater anti‐inflammatory and neuroprotective effects in a mouse model of stroke
ABSTRACT Our previous study has reported that the pentose phosphate pathway product nicotinamide adenine dinucleotide phosphate (NADPH) protected neurons against ischemia/reperfusion‐induced brain… Expand
Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury
In previous studies, we showed that TP53-induced glycolysis and apoptosis regulator (TIGAR) protects neurons against ischemic brain injury. In the present study, we investigated the developmental… Expand
Mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study
BackgroundMean platelet volume (MPV) is a marker of platelet activation. MPV and platelet count (PC) are negatively correlated, and their ratio (MPV/PC) is informative for the diagnosis of malignant… Expand
Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes Mellitus With and Without Cognitive Impairment
Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment. We investigated whether alterations of intranetwork and internetwork functional connectivity with T2DM progression exist, by… Expand
G6PD plays a neuroprotective role in brain ischemia through promoting pentose phosphate pathway.
- Lijuan Cao, Dingmei Zhang, +7 authors Z. Qin
- Biology, Medicine
- Free radical biology & medicine
- 1 November 2017
TIGAR-regulated pentose phosphate pathway (PPP) plays a critical role in the neuronal survival during cerebral ischemia/reperfusion. Glucose-6-phosphate dehydrogenase (G6PD) is a rate-limiting enzyme… Expand
SPOCD1 promotes the proliferation and metastasis of glioma cells by up-regulating PTX3.
- Q. Liu, X. Wang, +5 authors Jie-Min Zheng
- Biology, Medicine
- American journal of cancer research
- 1 April 2018
Gliomas are the most prevalent type of primary brain tumors in adults, accounting for more than 40% of neoplasms in the central nervous system. The spen paralogue and orthologue C-terminal domain… Expand
Genome-Wide Methylated DNA Immunoprecipitation Analysis of Patients with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a complex, heterogeneous disorder of uncertain etiology. Recent studies suggested that insulin resistance (IR) plays an important role in the development of PCOS.… Expand
Corrigendum to "Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke" [Free Radic. Biol. Med. 104 (2017) 333-345].