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Thalassospiramide G, a New γ-Amino-Acid-Bearing Peptide from the Marine Bacterium Thalassospira sp
TLDR
Thalassospiramides A and D inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells, with IC50 values of 16.4 and 4.8 μM, respectively. Expand
Effects of intra-articular SHINBARO treatment on monosodium iodoacetate-induced osteoarthritis in rats
TLDR
Intra-articular administration of SHINBARO (IAS) at 20 mg/kg remarkably restrained the decrease in bone volume/total volume and modulated the balance of inflammatory enzymes, mediators, and cytokines in the MIA-induced osteoarthritis rat model. Expand
In vitro stability and in vivo anti-inflammatory efficacy of synthetic jasmonates.
TLDR
In vivo evaluation of the stability-improved analogs showed that these compounds displayed higher efficacy than the lead J7, suggesting that these new jasmonate analogs may serve as potential anti-inflammatory leads. Expand
Suppression of Inducible Nitric Oxide Synthase Expression by Nyasol and Broussonin A, Two Phenolic Compounds from Anemarrhena asphodeloides, through NF‐κB Transcriptional Regulation in vitro and in
TLDR
Results suggest that the suppressive effects of nyasol and broussonin A on iNOS expression might provide one possible mechanism for their anti‐inflammatory activities. Expand
Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A₂A and A₃ adenosine receptor ligands.
TLDR
Truncated N(6)-substituted-4'-oxo- and 4'-thioadenosine derivatives with C2 or C8 substitution were studied as dual acting A(2A) and A(3) adenosine receptor (AR) ligands, and compound 4g was the most potent ligand acting dually as hA( 2A)AR agonist and hA (3)AR antagonist. Expand
Antitumor Activity of Spicatoside A by Modulation of Autophagy and Apoptosis in Human Colorectal Cancer Cells.
TLDR
Findings highlight the significance of 1 in the modulation of crosstalk between autophagy and apoptosis, as well as the potential use of 1 as a novel candidate in the treatment of human colorectal cancer cells. Expand
25-Methoxyhispidol A, a novel triterpenoid of Poncirus trifoliata, inhibits cell growth via the modulation of EGFR/c-Src signaling pathway in MDA-MB-231 human breast cancer cells.
TLDR
Findings suggest that 25-MHA-mediated inhibitory activity of human breast cancer cell growth might be related with the cell cycle arrest and modulation of signal transduction pathways. Expand
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
TLDR
The suppression of NF-κB activation and pro-inflammatory cytokine production may be a plausible mechanism of action for the anti-inflammatory activity of handelin. Expand
Abstract 1974: Growth inhibition and antitumor activity of chikusetsusaponin IVa methyl ester, an oleanane-type triterpenoid from the root ofAcyranthes japonica, in HCT 116 human colon cancer cells
TLDR
Findings suggest that CSME might be a potential candidate for the development of cancer chemotherapeutic agents derived from natural products. Expand
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