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Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.
- Y. Puius, Y. Zhao, M. Sullivan, D. Lawrence, S. Almo, Z. Zhang
- Medicine, Chemistry
- Proceedings of the National Academy of Sciences…
- 9 December 1997
The structure of the catalytically inactive mutant (C215S) of the human protein-tyrosine phosphatase 1B (PTP1B) has been solved to high resolution in two complexes. In the first, crystals were grown… Expand
The modular structure of actin-regulatory proteins.
Filamentous actin structures possess unique biophysical and biochemical properties and are required for cell locomotion, cell division, compartmentalization and morphological processes. The… Expand
Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Protein tyrosine phosphatase 1B (PTP1B) displays a preference for peptides containing acidic as well as aromatic/aliphatic residues immediately NH(2)-terminal to phosphotyrosine. The structure of… Expand
Mapping the functional surface of domain 2 in the gelsolin superfamily.
The crystal structure of the F-actin binding domain 2 of severin, the gelsolin homologue from Dictyostelium discoideum, has been determined by multiple isomorphous replacement and refined to 1.75 A… Expand
Lyme arthritis: pathogenesis, clinical presentation, and management.
Arthritis is one of the most prominent features of Lyme disease, the tick-borne illness caused by Borrelia burgdorferi. Although the pathogenesis of Lyme arthritis is complex and still under study,… Expand
Left ventricular assist device exchange for persistent infection: a case series and review of the literature
- D. Levy, Y. Guo, +5 authors G. Minamoto
- Transplant infectious disease : an official…
- 1 June 2014
Left ventricular assist device (LVAD) exchange for control of infection may be an option for the treatment of persistent and severe infections of the LVAD. Data are limited regarding the indications… Expand
Three cases of autoimmune hepatitis in HIV-infected patients.
- Y. Puius, L. Dove, D. Brust, D. Shah, J. Lefkowitch
- Journal of clinical gastroenterology
- 1 April 2008
Autoimmune hepatitis (AIH) is an uncommon liver disease that has previously been reported only 4 times in HIV-infected patients. Our report describes 3 new cases of AIH, 2 probable, and 1 definite.… Expand
Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(alpha 96Val-->Trp).
One of the most promising approaches for the development of a synthetic blood substitute has been the engineering of novel mutants of human hemoglobin (Hb) A which maintain cooperativity, but possess… Expand
Cardiac transplantation from non-viremic hepatitis C donors.
- S. Patel, S. Madan, +13 authors U. Jorde
- The Journal of heart and lung transplantation…
- 1 October 2018
BACKGROUND Hepatitis C (HCV) donors are rarely used for cardiac transplantation due to historically poor outcomes. In 2015, nucleic acid testing (NAT) for viral load was added to the routine work-up… Expand
Treatment of Candida albicans pericarditis in a heart transplant patient
Abstract: Pericarditis due to Candida species is a rare clinical entity, associated with thoracic surgery and immunosuppression. We report here the second case of pericarditis due to Candida albicans… Expand