• Publications
  • Influence
Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.
The structure of the catalytically inactive mutant (C215S) of the human protein-tyrosine phosphatase 1B (PTP1B) has been solved to high resolution in two complexes. In the first, crystals were grownExpand
  • 318
  • 11
  • PDF
The modular structure of actin-regulatory proteins.
Filamentous actin structures possess unique biophysical and biochemical properties and are required for cell locomotion, cell division, compartmentalization and morphological processes. TheExpand
  • 142
  • 7
Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Protein tyrosine phosphatase 1B (PTP1B) displays a preference for peptides containing acidic as well as aromatic/aliphatic residues immediately NH(2)-terminal to phosphotyrosine. The structure ofExpand
  • 108
  • 5
Mapping the functional surface of domain 2 in the gelsolin superfamily.
The crystal structure of the F-actin binding domain 2 of severin, the gelsolin homologue from Dictyostelium discoideum, has been determined by multiple isomorphous replacement and refined to 1.75 AExpand
  • 34
  • 2
  • PDF
Lyme arthritis: pathogenesis, clinical presentation, and management.
Arthritis is one of the most prominent features of Lyme disease, the tick-borne illness caused by Borrelia burgdorferi. Although the pathogenesis of Lyme arthritis is complex and still under study,Expand
  • 59
  • 1
Left ventricular assist device exchange for persistent infection: a case series and review of the literature
Left ventricular assist device (LVAD) exchange for control of infection may be an option for the treatment of persistent and severe infections of the LVAD. Data are limited regarding the indicationsExpand
  • 30
  • 1
Three cases of autoimmune hepatitis in HIV-infected patients.
Autoimmune hepatitis (AIH) is an uncommon liver disease that has previously been reported only 4 times in HIV-infected patients. Our report describes 3 new cases of AIH, 2 probable, and 1 definite.Expand
  • 32
  • 1
Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(alpha 96Val-->Trp).
One of the most promising approaches for the development of a synthetic blood substitute has been the engineering of novel mutants of human hemoglobin (Hb) A which maintain cooperativity, but possessExpand
  • 22
  • 1
Cardiac transplantation from non-viremic hepatitis C donors.
BACKGROUND Hepatitis C (HCV) donors are rarely used for cardiac transplantation due to historically poor outcomes. In 2015, nucleic acid testing (NAT) for viral load was added to the routine work-upExpand
  • 17
Treatment of Candida albicans pericarditis in a heart transplant patient
  • Y. Puius, B. Scully
  • Medicine
  • Transplant infectious disease : an official…
  • 1 September 2007
Abstract: Pericarditis due to Candida species is a rare clinical entity, associated with thoracic surgery and immunosuppression. We report here the second case of pericarditis due to Candida albicansExpand
  • 10