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The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation
Over the last decade, decreasing effectiveness of conventional antimicrobial-drugs has caused serious problems due to the rapid emergence of multidrug-resistant pathogens. Furthermore, biofilms,Expand
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Cell selectivity and mechanism of action of antimicrobial model peptides containing peptoid residues.
To develop a useful method for designing cell-selective antimicrobial peptides and to investigate the effect of incorporating peptoid residues into an alpha-helical model peptide on structure,Expand
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Antimicrobial activity studies on a trypsin-chymotrypsin protease inhibitor obtained from potato.
A 5.6 kDa trypsin-chymotrypsin protease inhibitor was isolated from the tubers of the potato (Solanum tuberosum L cv. Gogu) by extraction of the water-soluble fraction, dialysis, ultrafiltration, andExpand
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Colonization and Infection of the Skin by S. aureus: Immune System Evasion and the Response to Cationic Antimicrobial Peptides
Staphylococcus aureus (S. aureus) is a widespread cutaneous pathogen responsible for the great majority of bacterial skin infections in humans. The incidence of skin infections by S. aureus reflectsExpand
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Marine Peptides and Their Anti-Infective Activities
Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marineExpand
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Gram-positive bacteria specific properties of silybin derived fromSilybum marianum
Silybin has a potent antibacterial activity, more potent than silymarin II, against gram-positive bacteria without hemolytic activity, whereas it has no antimicrobial activity against gram-negativeExpand
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Investigation of toroidal pore and oligomerization by melittin using transmission electron microscopy.
We studied the effects of melittin on various cell wall components and vesicles of various lipid compositions. To interact with the cytoplasmic membrane, melittin must traverse the cell wall, whichExpand
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Design of novel peptide analogs with potent fungicidal activity, based on PMAP-23 antimicrobial peptide isolated from porcine myeloid.
PMAP-23 is a 23-mer peptide derived from porcine myeloid. To develop novel antifungal peptides useful as therapeutic drugs, it would require a strong fungicidal activity against pathogenic fungalExpand
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Antinematodal effect of antimicrobial peptide, PMAP‐23, isolated from porcine myeloid against Caenorhabditis elegans
The antinematodal activity and mechanism of a 23‐mer antimicrobial peptide, PMAP‐23, derived from pig myeloid was investigated. PMAP‐23 displayed a strong antinematodal activity against the eggs andExpand
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Antifungal Activity of (KW)n or (RW)n Peptide against Fusarium solani and Fusarium oxysporum
The presence of lysine (Lys) or arginine (Arg) and tryptophan (Trp) are important for the antimicrobial effects of cationic peptides. Therefore, we designed and synthesized a series of antimicrobialExpand
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