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HIF-1 in cancer therapy: two decade long story of a transcription factor
TLDR
New evidences indicate role of many HIF-induced proteomic and genomic alterations in malignant progression by mediating a myriad of genes stimulating angiogenesis, anaerobic metabolism and survival of cancer cells in O2-deficient microenvironment. Expand
Effect of Hippophae rhamnoides leaf extract against Dengue virus infection in human blood-derived macrophages.
TLDR
Observations suggest that the SBT leaf extract has a significant anti-dengue activity and has the potential for the treatment of Dengue. Expand
Anti-inflammatory activity of Seabuckthorn (Hippophae rhamnoides) leaves.
TLDR
Observations suggest that the SBT leaf extract has a significant anti-inflammatory activity and has the potential for the treatment of arthritis. Expand
Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway
TLDR
Results collectively show that EGCG acts as an mTOR inhibitor, SASP modulator as well as a potential senolytic agent thereby indicating its multi-faceted attributes that could be useful for developing anti-aging or age-delaying therapies. Expand
Dengue virus infection activates cellular chaperone Hsp70 in THP-1 cells: downregulation of Hsp70 by siRNA revealed decreased viral replication.
TLDR
Evidence is provided that an increased level of Hsp70 expression in dengue-virus-infected THP-1 cells assists in viral replication by escaping the antiviral effect of type 1 interferon. Expand
Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by HPTLC.
TLDR
The pharmacological evaluation of extract, fractions and pure molecules revealed the ethnomedicinal value of T. cordifolia for anticancer and immunomodulatory activities. Expand
Chemical Composition and In Vitro Cytotoxicity of Essential Oils from Leaves and Flowers of Callistemon citrinus from Western Himalayas
TLDR
Higher concentration of 1,8-cineole and/or synergistic effect of the overall composition were probably responsible for the efficacy of flower and leaf oils against the tested cells. Expand
Fatty acid composition, physicochemical properties, antioxidant and cytotoxic activity of apple seed oil obtained from apple pomace.
TLDR
The physicochemical properties of apple seed oil were comparable with edible food oil, indicating its better stability and broad application in the food and pharmaceutical industries, and its potential as an anticancer agent. Expand
In situ functionalized nanobiocomposites dressings of bamboo cellulose nanocrystals and silver nanoparticles for accelerated wound healing.
TLDR
Highly effective, biocompatible, and easy to apply NCs wound dressings (ointment and films) containing low amounts of Ag (0.05±0.01wt%) are potential candidates for effective skin repair. Expand
Effect of leaf extract of Seabuckthorn on lipopolysaccharide induced inflammatory response in murine macrophages.
TLDR
The study suggests that SBT leaf extract has significant anti-inflammatory activity and has potential for the treatment of inflammatory diseases. Expand
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