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Convenient synthesis of oxazolidinones by the use of halomethyloxirane, primary amine, and carbonate salt.
The present reaction can be widely applied to convenient synthesis of useful N-substituted oxazolidinones and chiral oxazolicinones.
Catalytic aerobic oxidation of nor-binaltorphimine (nor-BNI) analogs without 4,5-epoxy bridge affords a more selective ligand for kappa opioid receptor than the representative kappa antagonist
One of the oxidized nor-BNI analogs without 4,5-epoxy bridge, compound 18, showed high affinity and selectivity for kappa opioid receptor.
Structural properties of dibenzosuberanylpiperazine derivatives for efficient reversal of chloroquine resistance in Plasmodium chabaudi.
The results may lead to the development of an approach to developing clinically applicable chemosensitizers for drug-resistant malaria.
Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.
Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists.
Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.
A new useful conversion method of naltrexone to 14-deoxynaltrexone
A novel synthetic method of 14-deoxynaltrexone (2), a μ-opioid receptor antagonist possessing a new message-structural part of opioid ligands, was established. Naltrexone methyl ether (5) was first
A Practical Synthesis of Mannosaminyl-β(1→4)-glucosyl-α(1→2)-rhamnose, the Trisaccharide Repeating Unit of a Streptococcus pneumoniae Capsular Polysaccharide
An efficient chemical synthesis is described for the title trisaccharide repeating unit of the capsular polysaccharide of Streptococcus pneumoniae Type 19F, resulting in an altogether 6% overall yield for the 13 steps required from D-glucose.