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Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case–control study
TLDR
Ticlopidine-induced severe cholestatic hepatotoxicity occurred more frequently in subjects with HLA-A*3303 and its haplotype in Japanese patients, which may explain the high incidence. Expand
Multicenter prospective investigation on efficacy and safety of carperitide as a first-line drug for acute heart failure syndrome with preserved blood pressure: COMPASS: Carperitide Effects Observed
TLDR
Following carperitide monotherapy, 83.2% of AHFS patients recovered from the acute phase and improved the degree of dyspnea as assessed using the modified Borg scale, and car peritide seems useful for the first-line drug treatment ofAHFS in patients with pulmonary congestion and preserved blood pressure. Expand
An internally and externally validated nomogram for predicting the risk of irinotecan-induced severe neutropenia in advanced colorectal cancer patients
TLDR
The nomogram can be used before treatment to accurately predict the probability of irinotecan-induced severe neutropenia in the first cycle of therapy and should be used to evaluate the effect of nomogram-guided dosing on efficacy in patients receiving irinOTecan. Expand
[In vitro activity of sitafloxacin against clinical isolates in 2012].
TLDR
STFX showed the most potent activity against Gram-negative bacteria and anaerobic bacteria of all the antimicrobial agents tested in this study. Expand
Medication-taking behavior in hypertensive patients with a single-tablet, fixed-dose combination in Japan
TLDR
Use of single-tablet FDC antihypertensive therapy was associated with better medication-taking behavior and medication adherence measured by proportion of days covered by using a claims database. Expand
A Japanese case of vertebral sarcoidosis.
TLDR
This case suggests that MRI and 18F-FDG PET are useful for determining the site for a biopsy and that methotrexate (MTX) is effective for treating vertebral sarcoidosis. Expand
Impact of UGT1A1 genotype on prognosis in Japanese advanced colorectal cancer patients treated by irinotecan-based regimens.
TLDR
A prospective analysis to examine the correlation between UGT1A1 genotypes and safety/efficacy of IRI-based regimens in Japanese patients with advanced colorectal cancer and found no evidence of non-inferiority of hetero or homo to wild in progression-free survival (PFS) under the non- inferi... Expand
[Efficacy and safety of sitafloxacin in patients with urinary tract infections].
TLDR
It is suggested that STFX is a useful antibacterial agent with an efficacy rate of 91.4% against urinary tract infections, with a minimum efficacy rates of 87.2% (against complicated cystitis), and has no serious problems in its safety profile. Expand
Prospective analysis of UGT1A1 genotyping for predicting toxicities in advanced colorectal cancer (aCRC) treated with irinotecan (IRI)-based regimens: Interim safety analysis of a Japanese
TLDR
A prospective analysis to examine the correlation between UGT1A1 genotypes and the efficacy and safety of IRI-based regimens in Japanese aCRC patients found no relationship between these numbers and recommended IRI doses. Expand
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