Effect of JTH-601, a novel α1-adrenoceptor antagonist, on prostate function in dogs
Age-related change of the role of α1L-adrenoceptor
Inhibitory effect of JTV-803, a new cyclic guanidine derivative, on factor Xa in vitro and in vivo.
Effect of JTH-601, a novel alpha1-adrenoceptor antagonist, on the function of lower urinary tract and blood pressure.
Age-related change of the role of alpha1L-adrenoceptor in canine urethral smooth muscle.
- Y. Suzuki, N. Moriyama, Y. Okaya, H. Nishimatsu, K. Kawabe, K. Aisaka
- Biology, MedicineGeneral pharmacology
To examine age-related alteration of the role of alpha1L-adrenoceptor in the urethra, young non-parous and aged parous female dogs were used and specific binding of both JTH-601 and [3H]tamsulosin were observed in the bladder neck and proximal section of urethRA.
Distribution of α1L‐Adrenoceptors in Canine Prostate: Characterization by Quantitative Autoradiography
- Y. Suzuki, N. Moriyama, K. Aisaka
- Biology, MedicineThe Journal of pharmacy and pharmacology
- 1 June 2000
Our aim was to determine the distribution of α1L‐adrenoceptors in canine prostate by an autoradiographic technique using [3H]JTH‐601 (an α1L‐adrenoceptor antagonist) and [3H]JTH‐601‐G1 (an active…
Prostate selectivity of JTH‐601‐G1, an active metabolite of JTH‐601, in dogs
The effect of JTH‐601‐G1, an active metabolite and glucuronide conjugate of J TH‐601 (an α1‐adrenoceptor antagonist), on smooth muscle contraction in canine prostate and artery is evaluated.
The role of α1L-adrenoceptor in rat urinary bladder: Comparison between young adult and aged rats
The role of alpha 1L-adrenoceptor in rat urinary bladder: comparison between young adult and aged rats.
The results suggest that a facilitation of contractile response mediated by alpha1A-adrenoceptors may be a cause of unstable bladder in aged persons.
Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs.
JTH-601 is expected to be an effective alpha(1)-adrenoceptor antagonist for the treatment of urinary outlet obstruction by benign prostatic hypertrophy with a minimum effect on the cardiovascular system.