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New antibiotics, bleomycin A and B.
Cloning and sequence analysis of a protease-encoding gene from the marine bacterium Alteromonas sp. strain O-7.
- H. Tsujibo, K. Miyamoto, Y. Inamori
- Biology, ChemistryBioscience, biotechnology, and biochemistry
- 23 August 1996
The deduced amino acid sequence indicated that aprI codes for a precursor of 715 amino acids and the precursor is composed of four regions including a signal peptide, an N- terminal pro-region, a mature protease region and a C-terminal extension region of 215 amino acids as previously described for aprII.
Cloning, Sequence, andExpression ofa Chitinase Genefrom a MarineBacterium, Alteromonas sp.Strain 0-7
Characterization of Chitinase C from a Marine Bacterium, Alteromonas sp. Strain O-7, and Its Corresponding Gene and Domain Structure
To evaluate the role of the domain, the hybrid gene that directs the synthesis of the fusion protein with glutathione S-transferase activity was constructed, indicating that the N-terminal domain of ChiC constitutes an independent chitin-binding domain.
Studies on marine microorganisms. II. Actinomycetes in Sagami Bay and their antibiotic substances.
It was remarkable that the antibacterial spectra changed with varied cultural conditions, and 27 % of the isolates had antimicrobial activity and 17 % showed inhibition against Yoshida sarcoma cell.
Cloning, sequence, and expression of a chitinase gene from a marine bacterium, Altermonas sp. strain O-7
Regardless of origin, the enzymes of the two bacteria isolated from marine and terrestrial environments had high homology, suggesting that these organisms evolved from a common ancestor.
Site-directed mutagenesis of chitinase from Alteromonas sp. strain O-7.
- H. Tsujibo, H. Orikoshi, C. Imada, Y. Okami, K. Miyamoto, Y. Inamori
- BiologyBioscience, biotechnology, and biochemistry
- 23 August 1993
It is suggested that Asp-290 and Glu-292 of Chi85 may be the essential amino acid residues for the cleavage of beta-glycosidic linkage of chitin.
Metacytofilin, a novel immunomodulator produced by Metarhizium sp. TA2759.
Production of novel antibiotic, dopsisamine, by a new subspecies of Nocardiopsis mutabilis with multiple antibiotic resistance.
- A. Takahashi, K. Hotta, N. Saito, M. Morioka, Y. Okami, H. Umezawa
- BiologyThe Journal of antibiotics
- 1 February 1986
Physico-chemical and biological characterization of a purified antibiotic revealed its novel polyamine-type nature with a broad antimicrobial activity and was named dopsisamine.