Cellular proliferation in the anterior pituitary gland of normal adult rats: Influences of sex, estrous cycle, and circadian change
The cumulative incorporation of BrdU in females was consistently twice as high as in males over a constant period of time, and it is concluded that cell renewal occurs at a doubled rate in the pituitary of female rat.
Parous mammary glands exhibit distinct alterations in gene expression and proliferation responsiveness to carcinogenic stimuli in Lewis rats.
- N. Uehara, A. Unami, Y. Kiyozuka, N. Shikata, Y. Oishi, A. Tsubura
- BiologyOncology Report
- 1 April 2006
The response of AMV mammary glands to carcinogenic stimuli includes up-regulation of growth-related genes and increased cell proliferation, while the lack of a similar response in parous mammary gland may explain parity-induced protection against mammary tumor development.
Caspase-3 inhibitor rescues N -methyl- N -nitrosourea-induced retinal degeneration in Sprague-Dawley rats.
The use of a caspase-3 inhibitor was effective in the suppression of MNU-induced retinal apoptosis and may be a therapeutic intervention in human retinitis pigmentosa.
Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats.
The High Incidence of Atrial Thrombosis in Mice Given Doxorubicin
The cause of atrial thrombosis in DX-treated mice is unknown but may relate to endocardial damage and changes of blood flow in the atrium secondary to cardiac muscle damage.
Cataractogenesis in Neonatal Sprague-Dawley Rats by N-Methyl-N-Nitrosourea
The pathogenesis of MNU-induced cataract was associated with DNA adduct formation in the lens epithelial cell nuclei leading to apoptosis by upregulation of Bax protein, downmodulation of Bcl-2 protein, and activation of caspase-3.
Abdominal cysticercosis in a cynomolgus monkey.
Inhibitory potency of tacrolimus ointment on skin tumor induction in a mouse model of an initiation‐promotion skin tumor
Investigation of the skin tumorigenic potential of commercially available tacrolimus ointment in an I/P mouse model of skin tumors found tumor promotion effects on skin carcinogenesis were observed in the AO group, whereas inhibitory effects were seen in the MO group.
Congenital Intrahepatic Arteriovenous Fistulae in a Young Beagle Dog
Histopathologically, the atrophied hepatic lobes were characterized by wide, fibrous septa containing severe hyperplasia and anastomosis of the arteriolae and venulae and proliferation of bile ducts.
Mechanisms of photoreceptor cell apoptosis induced by N-methyl-N-nitrosourea in Sprague-Dawley rats.
- K. Yoshizawa, H. Nambu, A. Tsubura
- BiologyLaboratory investigation; a journal of technical…
- 1 November 1999
N-methyl-N-nitrosourea-induced photoreceptor cell death was attributed to DNA adduct formation restricted to photorecept cell nuclei leading to photoresceptor cell apoptosis by up-regulation of Bax protein, down-modulation of Bcl-2 protein, and activation of caspases 3, 6, and 8.