• Publications
  • Influence
Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.
TLDR
All the yeast and human DHHC genes are cloned and their intracellular localization and tissue-specific expression are investigated to aid in discovering the specific function(s) of each DHHC protein. Expand
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis
TLDR
It is established that ELOVL1 activity is regulated with the ceramide synthase CERS2, an enzyme essential for C24 sphingolipid synthesis, which may ensure that the production of C24-CoA by elongation is coordinated with its utilization. Expand
Zic2 regulates the kinetics of neurulation.
TLDR
Because the Zic2 knockdown mouse is the first mutant with HPE and spina bifida to survive to the perinatal period, the mouse will promote analyses of not only the neurulation but also the pathogenesis of human HPE. Expand
Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1, the Gene Responsible for Very-Long-Chain Fatty Acid Production
TLDR
Two ceramide synthases, CerS2 and CerS3, regulate Elovl1 to produce acyl coenzyme As with different chain lengths, which is a key determinant of epidermal Cer chain length and is essential for permeability barrier formation. Expand
Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane
TLDR
It is proposed that the inhibition of D-serine synthesis caused by translocation of SR to the membrane provides a fail-safe mechanism to prevent NMDAR overactivation in vicinal cells or synapses. Expand
Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system
TLDR
Twenty-one human DHHC proteins formed acyl intermediates and DHHC1, 10, 14, and 16 are novel protein acyltransferases, which are classified into three classes based on substrate specificities. Expand
Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation
TLDR
It is demonstrated that CYP4F22 is an ultra-long-chain fatty acid ω-hydroxylase responsible for acylceramide production and provide important insights into the molecular mechanisms of skin permeability barrier formation. Expand
Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation
TLDR
It is revealed that the two key players in ULC CER production in epidermis, CERS3 and ELOVL4, are coordinately regulated at both the transcriptional and enzymatic levels. Expand
Biochemical characterization of the very long‐chain fatty acid elongase ELOVL7
TLDR
Purified ELOVL7 exhibited high activity toward acyl‐CoAs with C18 carbon chain length and the calculated K m values toward C18:3(n‐3)‐ CoA and malonyl‐CoA were both in the μM range. Expand
Congenital myopathy is caused by mutation of HACD1
TLDR
It is suggested that the mutation in the HACD1 gene causes a reduction in the synthesis of VLCFAs, which are components of membrane lipids and participants in physiological processes, leading to congenital myopathy. Expand
...
1
2
3
4
5
...