Y. Nishiyama

Publications19
h-index6
Citations110
Highly Influential Citations5
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Novel Acrylonitrile Derivatives, YHO-13177 and YHO-13351, Reverse BCRP/ABCG2-Mediated Drug Resistance In Vitro and In Vivo
TLDR
It is suggested that Y HO-13351, a prodrug of YHO-13177, could be clinically useful for reversing BCRP-mediated drug resistance in cancer chemotherapy.
In vitro leukemia cell models of Ara-C resistance.
Rational Design of a Potent Pan-Pim Kinases Inhibitor with a Rhodanine-Benzoimidazole Structure.
TLDR
The data suggest that compound 2 can serve as a lead to novel anticancer agents, effective in the treatment of both solid carcinomas and hematological malignancies.
Detection of mutations in adenine phosphoribosyltransferase (APRT) deficiency using the LightCycler system
TLDR
It is demonstrated that the present system, using LightCycler technology, was simple, rapid, and reliable for detecting known mutations, and capable of identifying heterozygous and homozygous mutations in this family with APRT deficiency.
Novel Pan-Pim Kinase Inhibitors With Imidazopyridazine and Thiazolidinedione Structure Exert Potent Antitumor Activities
TLDR
Investigation of the preclinical profile of novel pan-Pim kinase inhibitors with imidazopyridazine and thiazolidinedione structure revealed that these compounds are novel Pim kinases inhibitors, effective on various types of cancer cell lines both in vitro and in vivo.
YPC‐21661 and YPC‐22026, novel small molecules, inhibit ZNF143 activity in vitro and in vivo
TLDR
The present study revealed that the inhibition of ZNF143 activity by small molecules induced tumor regression in vitro and in vivo; therefore, ZNF 143 is a promising target of cancer therapeutics.
[Fundamental evaluation of HCV core antigen method comparison with Cobas Amplicor HCV monitor v2.0 (high range method)].
TLDR
The HCV core Ag method seems to be useful as the quantitative measurement of HCV with respect to rapidness, easiness and low cost.
[Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia].
TLDR
It was concluded that the patient with chronic hepatitis C and type II cryoglobulinemia has suffered from lymphoproliferative disorder, namely HCV infection-associated primary macroglobULinemia.
F11-10 Usefulness of imiquimod in chronic hepatitis C
YHO-13351, a novel acrylonitrile derivative, reverses BCRP/ABCG2-mediated drug resistance in vitro and in vivo
TLDR
It is suggested that YHO-13351 could be a clinically useful drug to reverse BCRP-mediated drug resistance in cancer chemotherapy with CPT-11, mitoxantrone, or topotecan.
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