Y. Nishimura

Publications11
h-index3
Citations101
Highly Influential Citations16
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Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization
Cell polarization enables zygotes to acquire spatial asymmetry, which in turn patterns cellular and tissue axes during development. Local modification in the actomyosin cytoskeleton mediates spatial… Expand
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Extracting microtubule networks from superresolution single-molecule localization microscopy data
Microtubule filaments form ubiquitous networks. However, quantitative analysis of this structure is difficult due to its complex architecture. A tool is given for the automated retrieval of… Expand
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Cortical forces and CDC-42 control clustering of PAR proteins for C. elegans embryonic polarization
membrane potential. drp1 mutant PFCs also showed increased Ras and phosphorylated ERK and loss of Notch mediated differentiation. In order to dissect out the distinct roles of metabolism and… Expand
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Publisher Correction: A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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The Formin Inhibitor, SMIFH2, Inhibits Members of the Myosin Superfamily
The small molecular inhibitor of formin FH2 domains, SMIFH2, is widely used in cell biological studies. It was selected in a chemical screen as a compound inhibiting formin-driven actin… Expand
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mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse
mDia1/3 facilitate T cell receptor signaling via F-actin polymerization and are critical for T cell activation and development. The mechanism by which the cytosolic protein Zap70 physically interacts… Expand
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Microtubule regulation of integrin-based adhesions is mediated by myosin-IIA
The role of microtubules in the mechanoregulation of integrin-mediated adhesions is poorly understood. Here, we show that uncoupling of microtubules from integrin adhesions by depletion or… Expand
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Cortical contractility induces clustering of PAR proteins for embryonic polarization
The cytoskeleton as a smart composite material: A unified pathway linking microtubules, myosin-II filaments and integrin adhesions
The interrelationship between microtubules and the actin cytoskeleton in mechanoregulation of integrin-mediated adhesions is poorly understood. Here, we show that the effects of microtubules on two… Expand
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Title Project 7 Analyzing Tumor Microenvironment and Exploiting its Characteristics in Search of Optimizing Cancer Therapy Including Neutron Capture Therapy (28P7)