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NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in oral squamous cell carcinoma
Head and neck cancer, including oral squamous cell carcinoma, is the sixth most common cancer worldwide. Although cancer cell invasion and metastasis are crucial for tumor progression, detailedExpand
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Expression of MAS1 in breast cancer
MAS1 is a receptor for angiotensin 1‐7 (A1‐7), which is derived from angiotensin II (A‐II) by the action of angiotensin converting enzyme (ACE) 2. MAS1 induces anti‐A‐II phenotypes, such as vesselExpand
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Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines
The present study investigated the effects of two major dietary fatty acid components, linoleic acid (LA) and elaidic acid (EA), on the antitumor effects of 5-fluorouracil (5-FU) in the LL2, CT26 andExpand
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Concurrent Expression of CD47 and CD44 in Colorectal Cancer Promotes Malignancy
CD47 activates signal regulatory protein alpha expressed on macrophages and suppresses its phagocytic ability; therefore, CD47 is drawing attention as an immune checkpoint in the innate immuneExpand
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Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed the proliferation of CT26 mouse colon cancer cells
Normal and cancerous cells are suggested to have differential utilization of fatty acids and ketone bodies, which could be exploited in cancer therapy. The present study examined the effect ofExpand
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Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer.
Bladder cancer displays an aggressive phenotype in the muscle-invasive phase, and is associated with a high mortality rate. Therefore, novel molecular therapeutic targets are needed to improveExpand
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Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma
The renin-angiotensin system (RAS) is implicated in the maintenance of blood pressure and in many other biological processes including tumorigenesis and metastasis formation. Angiotensin-II (A-II)Expand
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Targeting claudin‐4 enhances chemosensitivity in breast cancer
Triple negative breast cancer (TNBC) is characterized by highly aggressive phenotype, limited treatment options and a poor prognosis. In the present study, we examined the therapeutic effect ofExpand
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Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas
Claudin (CLDN)-4 expression has been associated with malignancy in various cancers. When CLDN4 expression was examined in oral squamous cell carcinoma (OSCC), 22 out of 57 (39%) cases showedExpand
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Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells
The effects of trans-fatty acids (TFAs) on cardiovascular disorders have been extensively studied, and the effect of TFAs on cancers has recently been recognized. This study examined the effects ofExpand
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