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Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz‐F1 disrupted mice
TLDR
The present results clearly showed that the hypothalamic and pituitary Ad4BPs are essential to normal development of the functional VMH and gonadotroph through some mechanism distinct from that in the peripheral steroidogenic tissues.
Dose-response of a radiation induction of a germline mutation at a hypervariable mouse minisatellite locus.
TLDR
Dose-response of an induction of a germline mutation was studied at a hypervariable mouse minisatellite locus, Ms6hm, which consists of tandem repeats of a sequence motif GGGCA, and the spermatids stage was most sensitive to radiation and a statistically significant dose-response was observed.
Genomic organization and isoforms of the mouse ELP gene.
TLDR
expression of the four ELP isoforms was studied in mouse tissues and in tissue culture cells by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analysis and complex patterns of expression of these isoforms were observed in various tissues.
ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals
TLDR
A reactive oxygen species (ROS), H2O2 -responsive circadian pathway in mammals is identified and likely plays fundamental protective roles in various ROS-inducible disorders, diseases, and death.
Radiation-Induced Reactions in the Liver—Modulation of Radiation Effects by Lifestyle-Related Factors—
TLDR
Reactions to ionizing radiation in the liver are introduced, as demonstrated primarily in animal experiments, and modulation of radiation-induced effects in the Liver due to factors such as obesity, alcohol drinking, or supplements derived from foods are reviewed.
Characterization of Ninjurin and TSC22 induction after X-irradiation of normal human skin cells.
TLDR
Ninjurin and TSC22 induction after X-irradiation of normal human skin cells and the dependence of both gene expression on the status of an apoptosis regulator, p53, was found have important implications on the understanding of the mechanism underlying the complex response of skin cells following X-IRradiation.
Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells
TLDR
It is suggested that arsenite induces premature senescence as a result of DNA damage with heterochromatin forming through a p53/p21 dependent pathway following DNA damage.
Association of minisatellite instability with c-myc amplification and K-ras mutation in methylcholanthrene-induced mouse sarcomas.
TLDR
The present study indicates a possible involvement of K-ras mutation and c-myc amplification in induction of genetic instability in methylcholanthrene-induced mouse sarcomas.
Total body 100-mGy X-irradiation does not induce Alzheimer's disease-like pathogenesis or memory impairment in mice
TLDR
TBI induced early or late transcriptional alteration in only a few AD-related genes but did not significantly affect spatial learning, memory or AD-like pathological change in mice.
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