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Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer
TLDR
The results suggest that miRNAs may offer new biomarkers and therapeutic targets in epithelial ovarian cancer. Expand
Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus April 2012 edited by the Japan Esophageal Society
TLDR
These guidelines are intended for doctors who are engaged in the diagnosis and treatment of esophageal carcinoma to present the standard practice with a high regard for the principles of evidence-based medicine (EBM), and to improve the safety and results of treatment. Expand
Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung.
TLDR
It is demonstrated that NKX2-1 functions in a context-dependent manner in lung tumorigenesis and inhibits Kras(G12D)-driven mucinous pulmonary adenocarcinoma. Expand
Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells.
TLDR
L-Arginine regulates p70 S6 kinase activity and phosphorylation of 4E-BP1 through mTOR signaling pathway, which involves system y(+), cationic amino acid transporters. Expand
Gene signature driving invasive mucinous adenocarcinoma of the lung
TLDR
A Mucinous Lung Tumor Signature of 143 genes, which was unexpectedly enriched in mucin‐producing gastrointestinal, pancreatic, and breast cancers, is identified and ChIP‐seq combined with CRISPR/Cas9 determined that upstream enhancer regions of the mucin genes MUC5AC and M UC5B, which were bound by SPDEF, were required for the expression of the Mudin genes. Expand
Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma.
TLDR
There was no evidence to support the previously held view that Barrett adenocarcinoma is nearly always accompanied and preceded by intestinal-type mucosa, and it was not proven histogenetically that the background mucosa of esophageal adenOCarcinomas is the intestinal type. Expand
Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers.
TLDR
Evidence is provided for frequent MSH2 hypermethylation in Lynch syndrome tumors withMSH2 deficiency, which may serve as the "second hit" at the wild-type allele in this subset of individuals and raise the possibility that MSH 2 is a target susceptible to aberrant methylation inLynch syndrome. Expand
Analysis of fecal DNA methylation to detect gastrointestinal neoplasia.
TLDR
A novel strategy that uses single-step modification of DNA with sodium bisulfite and fluorescence polymerase chain reaction methodology to measure aberrant methylation in fecal DNA provides a possible means to noninvasive screen not only for colorectal tumors but also for gastric tumors. Expand
Antisense-mediated suppression of human heparanase gene expression inhibits pleural dissemination of human cancer cells.
TLDR
It is suggested that heparanase contributes to the invasive phenotype of tumor cells, and that antisense-mediated inhibition of heparinase activity may be efficacious in the prevention of pleural dissemination. Expand
Colonic interposition and supercharge for esophageal reconstruction
TLDR
For reconstruction of the esophagus, the colonic interposition and supercharge technique is advantageous and contributes to the patient’s quality of life. Expand
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