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Effects of Ortho‐dihydroxyisoflavone Derivatives from Korean Fermented Soybean Paste on Melanogenesis in B16 Melanoma Cells and Human Skin Equivalents
Results suggest that hydroxydaidzeins would be potent attenuators of melanin synthesis as well as effective inhibitors of hyperpigmentation in human skin. Expand
Mitochondrial dynamics regulate melanogenesis through proteasomal degradation of MITF via ROS‐ERK activation
  • Eun Sung Kim, So Jung Park, +10 authors Dong‐Hyung Cho
  • Biology, Medicine
  • Pigment cell & melanoma research
  • 1 November 2014
It is shown that mitochondrial dynamics regulate melanogenesis by modulating the ROS‐ERK signaling pathway and inhibition of ROS or ERK suppressed the antimelanogenic effect of mitochondrial fission in α‐MSH‐treated cells. Expand
[4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs.
Results indicate that phenyl-imidazole sulfonamide derivatives are potent c-kit inhibitors and might be used as skin-whitening agents. Expand
Protective effects of amentoflavone on Lamin A-dependent UVB-induced nuclear aberration in normal human fibroblasts.
Amentoflavone, a well known biflavonoid, inhibited the increase of Lamin A or phospho-H2AX protein in dose dependent manner which was induced by UVB irradiation, and also protected nuclear aberration dramatically. Expand
Amentoflavone Inhibits UVB-Induced Matrix Metalloproteinase-1 Expression Through the Modulation of AP-1 Components in Normal Human Fibroblasts
The major finding of this study shows that amentoflavone inhibits intracellular cell signaling ERK pathway leading to the prevention of MMP-1 expression in human skin fibroblasts, suggesting ament oflavone should be investigated as a potential agent for the prevention and the treatment of skin photoaging. Expand
Tensile stress regulation of NGF and NT3 in human dermal fibroblast
Fibroblast is constantly subjected to mechanical loads in connective tissues where mechanical signals are converted to intercellular biochemical events. The aim of this study is to understand theExpand
Soybean extract showed modulation of retinoic acid‐related gene expression of skin and photo‐protective effects in keratinocytes
  • N. Park, J-S Park, +5 authors Y. Na
  • Medicine, Chemistry
  • International journal of cosmetic science
  • 1 April 2013
It is found that soybean extract modulated retinoic acid‐related genes and showed photo‐protective effects, suggesting that soy bean extract could be an anti‐ageing ingredient that can be safely used under the sunlight. Expand
Depigmentation Effect of Kadsuralignan F on Melan-A Murine Melanocytes and Human Skin Equivalents
It is found that kadsuralignan F, a lignan from an extract of Kadsura coccinea, has an inhibitory activity on melanin synthesis through tyrosinase degradation. Expand
Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo
The present study demonstrates that the ethanolic bark extract of Alstonia scholaris R. Br. Expand
Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase.
It is suggested that coumestrol is a good candidate for use in depigmentary reagents from a cosmetic and clinical perspective because of its inhibitory effect on melanin synthesis in melan-a cells, at least in part through degradation of tyrosinase. Expand