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Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.
- S. Baba, N. Osakabe, +6 authors K. Kondo
- Chemistry, Medicine
- The American journal of clinical nutrition
- 1 March 2007
BACKGROUND Cocoa powder is rich in polyphenols such as catechins and procyanidins and has been shown in various models to inhibit LDL oxidation and atherogenesis. OBJECTIVE We examined whether… Expand
ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells.
Human bone marrow-derived mesenchymal stem cells (hMSCs) have the potential to differentiate into several types of cells. Calcium ions (Ca(2+)) play an important role in the differentiation and… Expand
CIP98, a novel PDZ domain protein, is expressed in the central nervous system and interacts with calmodulin‐dependent serine kinase
Receptors and various molecules in neurons are localized at precise locations to perform their respective functions, especially in synaptic sites. Among synaptic molecules, PDZ domain proteins play… Expand
PKC regulates the δ2 glutamate receptor interaction with S-SCAM/MAGI-2 protein
Abstract Inside cells, membrane proteins are localized at particular surface domains to perform their precise functions. Various kinds of PDZ domain proteins have been shown to play important roles… Expand
Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor δ2
- C. C. Yap, M. Murate, S. Kishigami, Y. Muto, R. Yano
- Biology, Medicine
- Molecular and Cellular Neuroscience
- 1 October 2003
Ion channels and receptors are targeted and localized at specific postsynaptic sites to mediate neurotransmission. Receptors clustering at postsynaptic sites has been extensively studied; however,… Expand
PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein.
- C. C. Yap, Y. Muto, H. Kishida, T. Hashikawa, R. Yano
- Biochemical and biophysical research…
Inside cells, membrane proteins are localized at particular surface domains to perform their precise functions. Various kinds of PDZ domain proteins have been shown to play important roles in the… Expand
Determination of rosmarinic acid and luteolin in Perilla frutescens Britton (Labiatae)
An analytical method for measuring rosmarinic acid (RA) and luteolin (Lut), the major polyphenolic substances in Perilla frutescens Britton (Labiatae) was established. High-performance liquid… Expand
Pharmacokinetic and Pharmacodynamic Properties of Biapenem, a Carbapenem Antibiotic, in Rat Experimental Model of Severe Acute Pancreatitis
Objectives: It is known that prophylaxis with imipenem reduces the risk of infection accompanying severe acute pancreatitis. In this study,we modified a rat experimental model of severe acute… Expand
Carboxypeptidase B inhibitors reduce tissue factor-induced renal microthrombi in rats.
- Y. Muto, K. Suzuki, E. Sato, H. Ishii
- Chemistry, Medicine
- European journal of pharmacology
- 14 February 2003
Procarboxypeptidase B (also known as thrombin-activatable fibrinolysis inhibitor) is a recently described plasma zymogen known to be activated by thrombin in plasma. Carboxy-terminal lysine residues… Expand
EF6265, a novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor, protects against sepsis-induced organ dysfunction in rats*
Objective:Although thrombin-activatable fibrinolysis inhibitor (TAFI) has been implicated as a negative regulator of fibrinolysis, its pathophysiological significance remains to be unveiled. We… Expand