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Dehydrodiisoeugenol, an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages.
Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and guaiacol in macrophages stimulated with lipopolysaccharide.
Among the 2-methoxyphenols, vanillin demonstrated a potent anti-inflammatory activity and the phenol function was crucial for eliciting this activity, making him attractive as a candidate therapeutic agent.
Radical scavenging activity and cytotoxicity of ferulic acid.
Results suggested that ferulic acid may be useful for preventing cell damage perhaps caused by O2-, and in particular by .OH and NO, in living systems.
Bacteroides (Porphyromonas) gingivalis fimbriae activate mouse peritoneal macrophages and induce gene expression and production of interleukin-1
Observations suggest that B. gingivalis fimbriae may be involved in the pathogenesis of adult periodontal disease via triggering of IL-1 production by monocytes/macrophage activation of peritoneal macrophages inperiodontal diseases.
Anti-inflammatory Activity of β-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species.
The anti-inflammatory activity of β-carotene, lycopene and TBB may be related to their ROS-scavenging activity and may be attributed to the electrophilicity of ROS-induced carotenoid intermediates and boranes, respectively.
Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression by eugenol-related compounds.
- N. Okada, A. Hirata, Y. Murakami, Masao Shoji, H. Sakagami, S. Fujisawa
- BiologyAnticancer research
- 1 September 2005
Eugenol-related compounds, particularly bis-EUG, may act as nonsteroidal anti-inflammatory drug (NSAID)-like compounds and be attributed to the inhibition of SOD mRNAs expression by the synergistic action of EUG and GSH or NAC.
Ferulic acid dimer inhibits lipopolysaccharide-stimulated cyclooxygenase-2 expression in macrophages.
Ferulic acid-related compounds were able to scavenge the stable 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and inhibition of COX-2 expression by compounds 2 and 3 could be caused by their increased phenolic function, which is associated with decreased anti-radical activity.
Frequency of reactivity for Porphyromonas gingivalis and Prevotella spp. in supra- and subgingival plaques, and periodontal clinical parameters according to subject age.
The IBA appears to be useful for the efficient and rapid detection of periodontopathic bacteria.
Dimerization, ROS formation, and biological activity of o-methoxyphenols.
- S. Fujisawa, T. Atsumi, Y. Murakami, Y. Kadoma
- Biology, ChemistryArchivum immunologiae et therapiae experimentalis
Dimerization of o-methoxyphenols may be a useful tool for the design of drugs to act as potent chemopreventive and anticancer agents.
Eugenol and Its Role in Chronic Diseases.
Dimmers of eugenol and its related compounds showed large antioxidant activities and high ω values and also exerted efficient anti-inflammatory activities, thus having the potential to alleviate and prevent chronic diseases.