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In vitro permeation of several drugs through the human nail plate: relationship between physicochemical properties and nail permeability of drugs.
The objectives of the present study are to clarify the relationship between the physicochemical properties and the nail permeability of drugs through human nail plates. Homologous p-hydroxybenzoicExpand
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Drug Permeation through the Three Layers of the Human Nail Plate
The in‐vitro permeation characteristics of a water soluble model drug, 5‐fluorouracil, and a poorly water soluble model drug, flurbiprofen, were investigated through three layers of the human nailExpand
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Enhancing effect of N-acetyl-l-cysteine or 2-mercaptoethanol on the in vitro permeation of 5-fluorouracil or tolnaftate through the human nail plate.
The enhancing effects of various vehicles on the in vitro permeation of a hydrophilic model drug, 5-fluorouracil (5-FU), or a lipophilic model drug, tolnaftate (TN), through human nail plates wereExpand
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Species differences in percutaneous absorption of nicorandil.
The species difference in skin permeability, Kp, of nicorandil was determined by using excised skin samples from hairless mouse, hairless rat, guinea-pig, dog, pig, and human. The Kp value ofExpand
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Prediction of Skin Permeability of Drugs: Comparison of Human and Hairless Rat Skin
Abstract— Relationships between skin permeability and physicochemical properties of drugs were examined to establish a predictive method for the steady‐state permeation rate of drugs through humanExpand
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Screening of cationic compounds as an absorption enhancer for nasal drug delivery.
Several cationic compounds were screened as potential nasal absorption enhancers to increase intranasal absorption of a model drug, fluorescein isothiocyanate labeled dextran (MW 4.4 kDa, FD-4),Expand
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Poly-l-Arginine Enhances Paracellular Permeability via Serine/Threonine Phosphorylation of ZO-1 and Tyrosine Dephosphorylation of Occludin in Rabbit Nasal Epithelium
AbstractPurpose. The purpose of the present study is to explore whether a poly-l-arginine (poly-l-Arg)-induced increase in tight junctions (TJ) permeability of fluorescein isothiocyanate-labeledExpand
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Acoustic cavitation as an enhancing mechanism of low-frequency sonophoresis for transdermal drug delivery.
We investigated the role of acoustic cavitation on sonophoretic skin permeation of calcein, a model permeant, across excised hairless rat skin. Three different frequencies (41, 158, 445 kHz) andExpand
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Mechanism of skin penetration-enhancing effect by laurocapram.
In order to clarify the mechanism of action of laurocapram (Azone) on the skin permeation of drugs, the following experiments were done. First, the effect of Azone on the skin components was comparedExpand
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Characterization of systemic and histologic injury after crush syndrome and intervals of reperfusion in a small animal model.
BACKGROUND Prolonged compression of limb muscles and subsequent decompression are important in the development of crush syndrome (CS). We applied a simple rubber tourniquet to rat hind limbs toExpand
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