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Synthesis and selective activity of cholinergic agents with rigid skeletons. II.
- S. Takemura, Y. Miki, M. Hoshida, M. Shibano, A. Suzuki
- Chemistry, MedicineChemical & pharmaceutical bulletin
- 25 October 1981
Cis-1-methylpiperidine-4, 3-acetolactone methiodide was designed and synthesized and showed no acetylcholine-like activity but did show a weak atropine-like antagonistic effect to acetyl choline.
[Cu(OH)(TMEDA)]₂Cl₂-catalyzed regioselective 2-arylation of 5-substituted tetrazoles with boronic acids under mild conditions.
- Takuya Onaka, Hideaki Umemoto, Y. Miki, A. Nakamura, T. Maegawa
- Medicine, ChemistryThe Journal of organic chemistry
- 7 July 2014
A mild and regioselective 2-arylation of 5-substituted tetrazoles is described, the first report of highly regiOSElective arylation of5-alkyltetrazoles, in the presence of [Cu(OH)(TMEDA)]2Cl2.
Evaluation of acid-labile S-protecting groups to prevent Cys racemization in Fmoc solid-phase peptide synthesis
- H. Hibino, Y. Miki, Y. Nishiuchi
- Chemistry, MedicineJournal of peptide science : an official…
- 28 November 2013
The 4,4′‐dimethoxydiphenylmethyl and 4‐methoxybenzyloxymethyl groups were demonstrated to be acid‐labile S‐protecting groups that can suppress racemization of Cys to an acceptable level when the respective Fmoc derivatives are incorporated via the standard SPPS protocol of phosphonium or uronium reagents with the aid of DIEA in DMF.
Determination of amikacin in human plasma by high-performance capillary electrophoresis with fluorescence detection.
A selective and reproducible high-performance capillary electrophoretic (HPCE) method for the quantification of amikacin (AMK), an aminocyclitol antibiotic, in human plasma, has been developed for…
In-capillary derivatization with 1-methoxycarbonylindolizine-3,5-dicarbaldehyde for high-performance capillary electrophoresis
A simple, selective and reproducible high-performance capillary electrophoresis (HPCE) assay with in-capillary derivatization using 1-methoxycarbonylindolizine-3,5-dicarbaldehyde (IDA) as a…
1-Methoxycarbonylindolizine-3,5-dicarbaldehyde as a derivatization reagent for amino compounds in high-performance capillary electrophoresis
The indolizine derivative 1-methoxycarbonylindolizine-3,5-dicarbaldehyde (IDA) was synthesized from 2-(1,3-dioxolan-2-yl)pyridine in four steps. The reactivity of the reagent towards primary amines…
Determination of amino acids by pre-column fluorescence derivatization with 1-methoxycarbonylindolizine-3,5-dicarbaldehyde
Abstract The fluorescence intensity of 15 amino acids and ammonia as their 1-methoxycarbonylindolizine-3,5-dicarbaldehyde (IDA) derivatives was investigated over the pH range 2–8. At pH 2–6, most…
Synthesis of 3-substituted pyrazolo[1,5-a]-pyridines by electrophilic reactions
Reactions of pyrazolo[1,5-a]pyridines with Eschenmoser's salt, activa- ted alkenes and alkynes, and chlorosulfonyl isocyanate provided general routes to 3-substituted pyrazolo[1,5-a]pyridines such as…
Paclitaxel-2′-Ethylcarbonate Prodrug Can Circumvent P-glycoprotein-mediated Cellular Efflux to Increase Drug Cytotoxicity
TAX-2′-Et can circumvent P-gp-associated cellular efflux of TAX and is converted into TAX by the Ra-CES, supporting its potential use as a theoretical GDEPT strategy for cancer cells expressing high levels of P- gp.
Protective effects of sarpogrelate, a 5-HT2A antagonist, against postischemic myocardial dysfunction in guinea-pig hearts
- T. Muto, Y. Hotta, +6 authors Y. Miki
- Chemistry, MedicineMolecular and Cellular Biochemistry
- 1 April 2005
Findings suggested that the 5-HT2A receptor induced in ischemia–reperfusion plays an important role in the mitochondrial KATP channel of hearts in close relation with NO and active oxygen radicals.