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Compartmentalized and Binary Behavior of Terminal Dendrites in Hippocampal Pyramidal Neurons
In response to fluorescence-guided focal photolysis of caged glutamate, individual terminal apical dendrites generated cadmium-sensitive all-or-none responses that were subthreshold for somatic action potentials. Expand
Targeting A-type K+ channels in primary sensory neurons for bone cancer pain in a rat model
It is reported that A‐type K+ channels in dorsal root ganglion (DRG) are involved in the neuropathy of rat bone cancer pain and are a new target for diclofenac, a nonsteroidal anti‐inflammatory drug that can be used for therapy for this distinct pain. Expand
Sigma ligands stimulate the electrical activity of frog pituitary melanotrope cells through a G-protein-dependent inhibition of potassium conductances.
Data indicate that DTG and (+)-pentazocine activate the electrical activity of cultured frog melanotrope cells by reducing both a tonic K+ current and a voltage-dependent [IK (V)] K+ conductance through the activation of a cholera toxin-sensitive G-protein. Expand
cAMP/protein kinase A signalling pathway protects against neuronal apoptosis and is associated with modulation of Kv2.1 in cerebellar granule cells
The protection against apoptosis via the protein kinase A pathway is associated with a double modulation on IK channel properties and its expression of α‐subunit that is mainly encoded by the Kv2.1 gene. Expand
The non-steroidal anti-inflammatory drug, diclofenac, inhibits Na(+) current in rat myoblasts.
It is demonstrated that diclofenac can inhibit the inward Na+ channels in rat myoblasts and both intracellular and extracellular application of the drug could inhibit I(Na), indicating thatdicl ofenac may exert its channel inhibitory action both inside and outside the channel sites. Expand
Arachidonic acid modulates Na+ currents by non-metabolic and metabolic pathways in rat cerebellar granule cells.
It is suggested that extracellular AA modulates Na(V) channel activity in rat cerebellar GCs without metabolic conversion, whereas intracellular AA augments the I(Na) by PGE(2)-mediated activation of cAMP/PKA pathways. Expand
Protective effect of oat bran extracts on human dermal fibroblast injury induced by hydrogen peroxide
The results demonstrate that oat peptides possess antioxidant activity and are effective against H2O2-induced human dermal fibroblast injury by the enhanced activity of SOD and decrease in MDA level. Expand
PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of IK in the anti‐apoptotic action of PACAP
In rat cerebellar granule cells, PACAP reduces the delayed outward rectifier K+ current by activating a type 1 PACAP (PAC1) receptor coupled to the adenylyl cyclase/protein kinase A pathway through a cholera toxin‐sensitive Gs protein. Expand
4-Aminopyridine, a Kv channel antagonist, prevents apoptosis of rat cerebellar granule neurons
  • Changlong Hu, Zheng Liu, +4 authors Y. Mei
  • Biology, Medicine
  • Neuropharmacology
  • 1 September 2006
The results suggest that 4-AP has robust neuroprotective effects on apoptotic granule cells, and may modulate the gating properties of IA channels in an anti-apoptotic manner. Expand
Melatonin receptor agonist 2‐iodomelatonin prevents apoptosis of cerebellar granule neurons via K+ current inhibition
The results suggest that the neuroprotective effects of melatonin are not only because of its function as a powerful antioxidant, but also to its interactions with specific receptors. Expand